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structure nameSTRUCTURE OF NF-KB P52 HOMODIMER BOUND TO P-SELECTIN KB DNA FRAGMENT
(Nuclear factor NF-kappa-B p52 subunit)
referenceMeshcheryakov et al. 'To ? ? ?
sourceHomo sapiens
experimentX-ray (resolution=3.00, R-factor=?)
structural superfamilyp53-like transcription factors;E set domains;
sequence familyRel homology domain RHD; IPT/TIG domain;
multimeric complexes7cli_AB 7vup_AB 7vuq_AB 7w7l_AB
redundant complexes7vup_A 7vuq_A 7w7l_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRYCESHK

Estimated binding specificities ?

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# IC=4.079 IC/col=1.020 n_of_columns=4 specificity:   
A |   3   0   2   1
C |   6   0   2   1
G |  82  96  88  86
T |   5   0   4   8
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RGRGYACCEC----SAHG------KG------------   L                                   +7cli_B    
                                                                             +-2 
  RGRGYA--EC------HG------KG------------   L                           +-----4 +7w7l_B    
                                                                       !     ! 
  RGRGYTCCEC------HG------KG------------   L                           !     +1a3q_A    
                                                         +-------------8 
  RCRCYC--EC------HC------KT------RG----   L             !             !      +1svc_P    
                                                         !             ! +----1 
  RGRGYTCCEC------HTKT----KT--PTKTRG----   L             !             ! !    +1nfk_A    
                                                         !             +-7 
  RGRGYTCCEC--------------KT------------   L             !               !    +2v2t_A    
                                                  +-----10               +----5 
  RGRGYTCTEC--------------RT------------   L      !      !                    ! +1gji_A    
                                                  !      !                    +-3 
  RGRG----EC--------------RG--PTKT------   L      !      !                      +2ram_A    
                                                  !      !  
  RGRG----EG--RG------------------------   L   +-11      !     +-------------1bvo_A    
                                               !  !      +-----9 
  RG--YT--TTEC----RG----------QA--------   L   !  !            +-------------1imh_C    
                                               !  !  
  RGRGYT--EC----------KTTTQART----------   L -12  !                         +1a66_A    
                                               !  +-------------------------6 
  RG--YT--TTEC----RG------QA------------   L   !                            +1p7h_L    
                                               !  
  ----------------------------------RAVC   L   +----------------------------6vgd_D    
                                             

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updated Wed Dec 18 08:24:27 2024