7prw_B : 3D-footprint complex

structure name	THE GLUCOCORTICOID RECEPTOR IN COMPLEX WITH VELSECORAT, A PGC1A COACTIVATOR FRAGMENT AND SGK 23BP (Glucocorticoid receptor)
reference	Wissler et al. Nat.Struct.Mol.Biol. 30 286 2023
source	Homo sapiens
experiment	X-ray (resolution=2.50, R-factor=0.205)
structural superfamily	Nuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
sequence family	Ligandbinding domain of nuclear hormon; Zinc finger, C4 type two domains;
multimeric complexes	7prv_AB 7prw_AB
redundant complexes	7prv_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7prw_B interface=25,26,30, pklclvcsdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqmiaavkwakaipgfrnlhlddqmtllqyswmslmafalgwrsyrqssanllcfapdliineqrmtlpdmydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikkllfhqk
interface signature	KVR

Estimated binding specificities ?

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# IC=3.912 IC/col=0.782 n_of_columns=5

specificity:

A |   0   9  39   0  96
C |   0  19  19  96   0
G |  86  49  19   0   0
T |  10  19  19   0   0

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Dendrogram of similar interfaces ?

matrix format

  
  --ECKGAG--RG----   L           +-----------------------------4ond_A    
                               +-2 
  ----KGVT--RG----   L       +-3 +-----------------------------2c7a_B    
                             ! ! 
  --ECKGAG--KTRG--   L     +-4 +-----------------------------4aa6_B    
                           ! ! 
  CAECKG--KGRG----   L     ! !                         +---1cit_A    
                         +-5 +-------------------------1 
  --EAKG--KTRG----   L   ! !                           +---4umm_A    
                       --6 ! 
  --EAKG--RTRT--RT       ! +-----------------------------4umm_E    
                         ! 
  --ECKG----RA----   L   +-----------------------------5krb_G

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updated Sat Jan 10 17:07:57 2026