7xv6_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE HUMAN TR4 DNA-BINDING DOMAIN WITH C-TERMINAL EXTENSION (DBD-CTE) HOMODIMER BOUND TO DR1 RESPONSE ELEMENT (NR2C2 protein)
reference	Chen et al. 'Nucleic 51 1443 2023
source	Homo sapiens
experiment	X-ray (resolution=2.30, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
sequence family	Zinc finger, C4 type two domains;
multimeric complexes	7xv6_AB 7xv8_AB
redundant complexes	7xv8_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7xv6_B interface=23,26,30,31, vveycvvcgdkasgrhygavscEgcKgffKRsvrknltyscrsnqdciinkhhrnrcqfcrlkkclemgmkmesvqs
interface signature	EKKR

Estimated binding specificities ?

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# IC=4.887 IC/col=0.977 n_of_columns=5

specificity:

A |  20   0  76   0   0
C |  19   0   0  96  96
G |  19  96  20   0   0
T |  38   0   0   0   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --EAKG--RTRT--RT                                  +4umm_E    
                                                +---1 
  CAECKG--KGRG----   L               +----------4   +1cit_A    
                                     !          ! 
  --ECKGAG--RG----   L               !          +---4ond_A    
                                   +-6 
  --ECKG----RA----   L             ! !          +---5krb_G    
                                   ! +----------5 
  ----KGVT--RG----   L             !            !   +5emc_A    
                         +---------7            +---3 
  --ECKGAG--KTRG--   L   !         !                +4aa6_B    
                         !         ! 
  --EAKG--KTRG----   L --8         !               +4umm_A    
                         !         +---------------2 
  ----KGVG--RG----   L   !                         +4tnt_B    
                         ! 
  ----KGVT--RG----   L   +-------------------------2c7a_B

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updated Tue Jun 30 11:53:49 2026