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structure nameCRYSTAL STRUCTURE OF THE HUMAN FOXA2 BOUND TO THE TGTTTACT SITE (FORKHEAD MOTIF GTAAACA)
(Hepatocyte nuclear factor 3-beta)
referenceMacias et al. 'To ? ? 2022
sourceHomo sapiens
experimentX-ray (resolution=1.99, R-factor=0.209)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
redundant complexes7yzf_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHSF

Estimated binding specificities ?

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# IC=6.437 IC/col=0.920 n_of_columns=7 specificity:   
A |   8   8  11   0   0  96   8
C |   1   8   8   0   0   0   8
G |   0  69   8   0   0   0  69
T |  87  11  69  96  96   0  11
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Dendrogram of similar interfaces ?

matrix format
  
  ----------------NASTRGHT--STLT--------   L                                +7cby_C    
                                                                       +----1 
  ----------------NASTRGHT--STFT--------   L               +-----------2    +1vtn_C    
                                                           !           ! 
  ----------------NASTRTHT--STLT--------   L        +------4           +-----4lg0_A    
                                                    !      ! 
  ----------------RC----YG--------------          +-7      +-----------------2acj_B    
                                                  ! ! 
  RT--LA--NTHGTTETYTRG------------------   L      ! +------------------------1f4k_B    
                                                  ! 
  ------ST--------NASTRTHT--ST----------   L   +--8               +---------3l2c_A    
                                               !  !    +----------3 
  ----------------RGNTRGSTAT--RA--------   L   !  ! +--5          +---------2o6g_G    
                                               !  ! !  ! 
  ----------RGSTRTSTHG----------------RA   L --9  +-6  +--------------------3zpl_B    
                                               !    ! 
  --TT--------KATTQTTG--LTRT----KA------   L   !    +-----------------------2p7c_B    
                                               ! 
  --------------------------------KGKG--   L   +---------------------------5xfq_A    
                                             

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updated Tue Jun 30 12:26:49 2026