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structure nameCRYSTAL STRUCTURE OF THE HUMAN FOXA2 BOUND TO THE TGTTTACT SITE (FORKHEAD MOTIF GTAAACA)
(Hepatocyte nuclear factor 3-beta)
referenceMacias et al. 'To ? ? 2022
sourceHomo sapiens
experimentX-ray (resolution=1.99, R-factor=0.209)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
redundant complexes7yzf_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHSF

Estimated binding specificities ?

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# IC=5.602 IC/col=0.934 n_of_columns=6 specificity:   
A |   0  96  96  44   0  85
C |   0   0   0  10  64   0
G |   0   0   0  21  21  10
T |  96   0   0  21  11   1
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Dendrogram of similar interfaces ?

matrix format
  
  ----------------NASTRGHT--STLT----   L                     +------7cby_C    
                                                 +-----------1 
  ------ST--------NASTRTHT--ST------   L     +---2           +------3l2c_A    
                                             !   ! 
  RT--LA--NTHGTTETYTRG--------------   L   +-3   +------------------1f4k_B    
                                           ! ! 
  ----------RGSTRTSTHG------------RA   L --4 +----------------------3zpl_B    
                                           ! 
  --TT--------KATTQTTG--LTRT----KA--   L   +------------------------2p7c_B    
                                         

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updated Wed Dec 18 14:50:47 2024