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structure nameCRYSTAL STRUCTURE OF THE HUMAN FOXA2 BOUND TO THE TGTTTACT SITE (FORKHEAD MOTIF GTAAACA)
(Hepatocyte nuclear factor 3-beta)
referenceMacias et al. 'To ? ? 2022
sourceHomo sapiens
experimentX-ray (resolution=1.99, R-factor=0.209)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
redundant complexes7yzf_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHSF

Estimated binding specificities ?

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# IC=6.429 IC/col=0.918 n_of_columns=7 specificity:   
A |   2   0  96  96  52  10  96
C |  69   0   0   0  19  61   0
G |  17   0   0   0   8   8   0
T |   8  96   0   0  17  17   0
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Dendrogram of similar interfaces ?

matrix format
  
  ----------------NASTRGHT--STLT----   L                           +7cby_C    
                                                              +----1 
  ----------------NASTRGHT--STFT----   L        +-------------3    +1vtn_C    
                                                !             ! 
  ----------------NASTRTHT--STLT----   L   +----5             +-----4lg0_A    
                                           !    ! 
  ----------RGSTRTSTHG------------RA   L   !    !                  +3zpl_B    
                                           !    +------------------2 
  ----------------RC----YG----------       !                       +2acj_B    
                                         --8 
  ------ST--------NASTRTHT--ST------   L   !               +---------3l2c_A    
                                           !    +----------4 
  ----------------RGNTRGSTAT--RA----   L   ! +--6          +---------2o6g_G    
                                           ! !  ! 
  --TT--------KATTQTTG--LTRT----KA--   L   +-7  +--------------------2p7c_B    
                                             ! 
  RT--LA--NTHGTTETYTRG--------------   L     +-----------------------1f4k_B    
                                         

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updated Sat Jan 10 21:04:41 2026