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structure nameCRYSTAL STRUCTURE OF THE HUMAN FOXA2 BOUND TO THE TGTTTACT SITE (FORKHEAD MOTIF GTAAACA)
(Hepatocyte nuclear factor 3-beta)
referenceMacias et al. 'To ? ? 2022
sourceHomo sapiens
experimentX-ray (resolution=1.99, R-factor=0.209)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
redundant complexes5x07_L 7yzf_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHSF

Estimated binding specificities ?

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# IC=6.108 IC/col=0.873 n_of_columns=7 specificity:   
A |   7  14  16   0   0  96  14
C |   0   9  14   0   0   0  14
G |   1  66   7   0   0   0  61
T |  88   7  59  96  96   0   7
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------------------QTNASTRGHTNTSTLART--   L             +-----------------------------2hdc_A    
                                                           +-1 
  --------FG----TTPTRTAT----LT--------------   L         +-2 +-----------------------------4hqe_A    
                                                         ! ! 
  ----------YC--KTHGSTQT--YTPT------------LG   L       +-3 +-----------------------------5x11_A    
                                                       ! ! 
  ------------------------RTNTRGST--NGRT----   L     +-4 +-----------------------------2pi0_B    
                                                     ! ! 
  ------------NG----RGRG--YC----------------   L   +-5 +-----------------------------1cf7_B    
                                                   ! ! 
  ----------------RC--------YC--------------   L --6 +-----------------------------7cc9_A    
                                                   ! 
  LAHAKARA----------------------------------       +-----------------------------6dta_A    
                                                 

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updated Wed Dec 20 00:21:05 2023