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structure nameCRYSTAL STRUCTURE OF THE HUMAN FOXA2 BOUND TO THE TGTTTACT SITE (FORKHEAD MOTIF GTAAACA)
(Hepatocyte nuclear factor 3-beta)
referenceMacias et al. 'To ? ? 2022
sourceHomo sapiens
experimentX-ray (resolution=1.99, R-factor=0.209)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
redundant complexes7yzf_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHSF

Estimated binding specificities ?

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# IC=5.446 IC/col=0.908 n_of_columns=6 specificity:   
A |   0  96  96  60  12  84
C |   0   0   0  12  48   0
G |   0   0   0  12  12  12
T |  96   0   0  12  24   0
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Dendrogram of similar interfaces ?

matrix format
  
  ----------------NASTRGHT--STLT----   L                +-------7cby_C    
                                                      +-1 
  ------ST--------NASTRTHT--ST------   L       +------2 +-------3l2c_A    
                                               !      ! 
  ----------RGSTRTSTHG------------RA   L   +---3      +---------3zpl_B    
                                           !   ! 
  RT--LA--NTHGTTETYTRG--------------   L --4   +----------------1f4k_B    
                                           ! 
  --TT--------KATTQTTG--LTRT----KA--   L   +--------------------2p7c_B

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updated Sat Sep 14 07:52:24 2024