8j9v_A : 3D-footprint complex

structure name	CRYO-EM STRUCTURE OF THE AFRICAN SWINE FEVER VIRUS TOPOISOMERASE 2 COMPLEXED WITH CUT02ADNA AND ETOPOSIDE (EDI-1)
experiment	NMR
structural superfamily	Type II DNA topoisomerase;
sequence family	DNA gyrase/topoisomerase IV, subunit A 2222;
multimeric complexes	8kgm_AB 8kgn_AB 8kgq_AB 8kgr_AB
redundant complexes	8j9w_B 8j9x_A 8kgm_B 8kgn_B 8kgq_A 8kgr_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8j9v_A interface=59,133,292,343,437,438,443, vdkytrarnaggkraqdcmllaaegdsalsllrtgltlgksnpsgpsfdfcgmislggVimnackkvtnittdsgetimvrneqltnnkvlqgivqvlgldfnchyktqeeraklrygcivacvdqdldgcgKilglllayfhlfwpqliihgfvkrlltplirvyekgktmpvefyyeqefdawakkqtslvnhtvkyykglaahdthevksmfkhfdnmvytftlddsakelfhiyfggeselrkrelctgvvpltetqtqsihsvrripcslhlqvdtkaykldaierQipnfldgmtrarrkilaggvkcfasnnrerkvfqfggyvadhmfyhhgdmSlntsiikaaqyypgsshlypvfigigsfgsrhlggkdagspryisvqlasefiktmfpaedswllpyvfedgqraepeyyvpvlplaimeygaNPsegwKyttwarqledilalvrayvdkdnpkhellhyaikhkitilplrpsnynfkghlkrfgqyyysygtydiseqrniititelplrvptvayiesikkssnrmtfieeiidysssetieilvklkpnslnriveefketeeqdsienflrlrnclhshlnfvkpkggiiefnsyyeilyawlpyrrelyqkrlmrehavlklriimetaivryinesaelnlshyedekeasrilsehgfpplnhtliispefasieelnqkalqgcytyilslqarelliaaktrrvekikkmqarldkveqllqespfpgasvwleeidavekaiikgrntqwkfh
interface signature	VKQSNPK

Estimated binding specificities ?

readout + contact

# IC=5.300 IC/col=0.883 n_of_columns=6

specificity:

A |   9  11   0   0  96   9
C |   9  67  96   0   0  67
G |  67   9   0   0   0  11
T |  11   9   0  96   0   9

scan!

Dendrogram of similar interfaces ?

matrix format

  
  KA--SA------------RGIG------------------------------             +-----------------------------2xcr_U    
                                                                 +-1 
  --RCST--------------IA------------------------------         +-2 +-----------------------------3ksb_B    
                                                               ! ! 
  ----------------------DGICLGWGQGKTLTKGFGFG----------   L   +-3 +-----------------------------4y0f_A    
                                                             ! ! 
  ------------------------------------------NTATATSTRG   L --4 +-----------------------------1dh3_C    
                                                             ! 
  ------NASTRGHTSTLT----------------------------------   L   +-----------------------------7cby_C

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updated Sat Sep 14 11:07:32 2024