interface graph thumbnail
legend  pdf

structure nameCRYO-EM STRUCTURE OF THE AFRICAN SWINE FEVER VIRUS TOPOISOMERASE 2 COMPLEXED WITH CUT02ADNA AND ETOPOSIDE (EDI-1)
experimentNMR
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A 2222;
multimeric complexes8kgm_AB 8kgn_AB 8kgq_AB 8kgr_AB
redundant complexes8j9w_B 8j9x_A 8kgm_B 8kgn_B 8kgq_A 8kgr_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureVKQSNPK

Estimated binding specificities ?

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# IC=5.379 IC/col=0.896 n_of_columns=6 specificity:   
A |   9   0  96   0   9   9
C |   9   0   0   0  11  69
G |  69   0   0  96  67   9
T |   9  96   0   0   9   9
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Dendrogram of similar interfaces ?

matrix format
  
  KA--SA------------RGIG------------------------------             +-----------------------------2xcr_U    
                                                                 +-1 
  --RCST--------------IA------------------------------         +-2 +-----------------------------3ksb_B    
                                                               ! ! 
  ----------------------DGICLGWGQGKTLTKGFGFG----------   L   +-3 +-----------------------------4y0f_A    
                                                             ! ! 
  ------------------------------------------NTATATSTRG   L --4 +-----------------------------1dh3_C    
                                                             ! 
  ------NASTRGHTSTLT----------------------------------   L   +-----------------------------7cby_C    
                                                           

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updated Wed Dec 18 18:34:58 2024