interface graph thumbnail
legend  pdf

structure nameTHREE-DIMENSIONAL STRUCTURE OF S.AUREUS METHICILLIN-RESISTANCE REGULATING TRANSCRIPTIONAL REPRESSOR MECI IN COMPLEX WITH 25-BP DS- DNA
(Methicillin resistance regulatory protein mecI)
referenceMallorqui-Fernandez et al.
sourceStaphylococcus aureus subsp. aureus
experimentX-ray (resolution=2.80, R-factor=0.216)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyPenicillinase repressor;
multimeric complexes1sax_AB 2d45_AB 2d45_CD
redundant complexes2d45_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKTRTLR

Estimated binding specificities ?

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# IC=5.089 IC/col=0.727 n_of_columns=7 specificity:   
A |  19  96  24   9  96   0  57
C |   9   0  24  19   0  96  11
G |   1   0  24  11   0   0   9
T |  67   0  24  57   0   0  19
scan!

Dendrogram of similar interfaces ?

matrix format
  
  TT------KATTQTTG--LTRT----KA----FTYT   L                          +--------2p7c_B    
                                                     +--------------3 
  ------------NASTRGHT--STFT----------   L           !              +--------1vtn_C    
                                               +-----5 
  ----DCLT--AGTTRG----RG--------RA----   L     !     !                       +5h3r_A    
                                             +-6     +-----------------------1 
  --------------RC--YG--------KT------       ! !                             +2acj_B    
                                             ! ! 
  ------------------YG----------------       ! +-----------------------------3eyi_B    
                                           --7 
  ------------NASTRTHT--ST------------   L   !                         +---3l2c_A    
                                             !                   +-----2 
  ------------NASTRGHT--STLT----------   L   +-------------------4     +---7cby_C    
                                                                 ! 
  --LANTHGTTETYTRG--------------------   L                       +---------1f4k_B    
                                           

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updated Sat Jan 10 04:56:29 2026