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structure nameTHREE-DIMENSIONAL STRUCTURE OF S.AUREUS METHICILLIN-RESISTANCE REGULATING TRANSCRIPTIONAL REPRESSOR MECI IN COMPLEX WITH 25-BP DS- DNA
(Methicillin resistance regulatory protein mecI)
referenceMallorqui-Fernandez et al.
sourceStaphylococcus aureus subsp. aureus
experimentX-ray (resolution=2.80, R-factor=0.216)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyPenicillinase repressor;
multimeric complexes1sax_AB 2d45_AB 2d45_CD
redundant complexes2d45_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKTRTLR

Estimated binding specificities ?

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# IC=5.092 IC/col=0.727 n_of_columns=7 specificity:   
A |  16  96  24   8  96   0  64
C |   8   0  24  24   0  96   8
G |   8   0  24   8   0   0   8
T |  64   0  24  56   0   0  16
scan!

Dendrogram of similar interfaces ?

matrix format
  
  TT------KATT--QTTG--LTRT----KA----FTYT   L           +-----------------------------2p7c_B    
                                                     +-2 
  ----DCLT--AG--TTRG----RG--------RA----   L       +-3 +-----------------------------5h3r_A    
                                                   ! ! 
  --------------------YG----------------         +-4 +-----------------------------3eyi_B    
                                                 ! ! 
  --------------NASTRTHT--ST------------   L   +-5 +-----------------------------3l2c_A    
                                               ! ! 
  --------------NASTRGHT--STLT----------   L   ! !                     +-------7cby_C    
                                             --6 +---------------------1 
  --LANTHGTTET--YTRG--------------------   L   !                       +-------1f4k_B    
                                               ! 
  ------PTPG--TT----------------HG------   L   +-----------------------------7d98_Q

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updated Tue Dec 17 22:22:06 2024