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structure namePHAGE-SELECTED HOMEODOMAIN BOUND TO UNMODIFIED DNA
(Segmentation polarity homeobox protein engrailed)
referenceFeldman et al. 'Acs 1 755 2006
sourceDrosophila melanogaster
experimentX-ray (resolution=1.90, R-factor=0.225)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes2hos_AB 2hot_AB
redundant complexes2hot_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKN

Estimated binding specificities ?

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# IC=5.166 IC/col=0.861 n_of_columns=6 specificity:   
A |   0  72  96   8   0   8
C |   8   8   0   8  96  69
G |   1   8   0  11   0   8
T |  87   8   0  69   0  11
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ENGRAILED
TAATTAPubMed2hos_A(1.21e-03), 2hot_A(3.57e-04)
TAATCCPubMed2hos_A(4.53e-11), 2hos_AB(6.43e-08), 2hot_AB(5.23e-08), ... (total=4)
CGCATCCCCPubMed2hos_A(1.05e-02)
TTAATTPubMed2hos_A(1.21e-03), 2hot_A(3.57e-04)
TAATNNPubMed2hos_A(1.21e-03), 2hot_A(3.57e-04)

Dendrogram of similar interfaces ?

matrix format
  
  --VTKGNA--KA--   L     +-----------------------------2lkx_A    
                         ! 
  QTVAQTNA------   L     !                            +8osb_E    
                         !             +--------------1 
  --IAQCNAMG----   L   +-5        +----2              +1b72_A    
                       ! !        !    ! 
  --NCICRG------   L   ! !     +--3    +---------------4xrm_B    
                       ! !     !  ! 
  --IAQCNAYC----   L --6 +-----4  +--------------------3rkq_B    
                       !       ! 
  --VTCCNAQA--RT   L   !       +-----------------------8g87_X    
                       ! 
  --------YCFAKC   L   +-----------------------------6pe2_B

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updated Tue Dec 17 22:48:14 2024