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structure namePHAGE-SELECTED HOMEODOMAIN BOUND TO UNMODIFIED DNA
(Segmentation polarity homeobox protein engrailed)
referenceFeldman et al. 'Acs 1 755 2006
sourceDrosophila melanogaster
experimentX-ray (resolution=1.90, R-factor=0.225)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes2hos_AB 2hot_AB
redundant complexes2hot_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKN

Estimated binding specificities ?

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# IC=5.105 IC/col=0.851 n_of_columns=6 specificity:   
A |  11   0  69   0   8  87
C |   8   0   8   0  11   1
G |  69  96   8   0   8   8
T |   8   0  11  96  69   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ENGRAILED
TAATTAPubMed2hos_A(1.21e-03), 2hot_A(3.57e-04)
TAATCCPubMed2hos_A(4.53e-11), 2hos_AB(6.43e-08), 2hot_AB(5.23e-08), ... (total=4)
CGCATCCCCPubMed2hos_A(1.05e-02)
TTAATTPubMed2hos_A(1.21e-03), 2hot_A(3.57e-04)
TAATNNPubMed2hos_A(1.21e-03), 2hot_A(3.57e-04)

Dendrogram of similar interfaces ?

matrix format
  
  ----NT--NAIARG--   L   +-----------------------------1b72_B    
                         ! 
  ----VTKGNA--KA--   L   !                               +2lkx_A    
                         !                           +---1 
  ----IAQTNA------   L   !          +----------------4   +5ego_B    
                         !          !                ! 
  RT--NT--NAIARG--   L   !          !                +---4cyc_B    
                       --9          ! 
  --QTVAQTNA------   L   !    +-----6                   +8osb_E    
                         !    !     !                 +-2 
  ----IAQCNAMG----   L   !    !     !       +---------3 +1b72_A    
                         !    !     !       !         ! 
  ----NCICRG------   L   !  +-7     +-------5         +--4xrm_B    
                         !  ! !             ! 
  ----IAQCNAYC----   L   !  ! !             +------------3rkq_B    
                         +--8 ! 
  ----VTCCNAQA--RT   L      ! +--------------------------8g87_X    
                            ! 
  ----------YCFAKC   L      +--------------------------6pe2_B

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updated Sat Jan 10 05:17:38 2026