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structure namePHAGE-SELECTED HOMEODOMAIN BOUND TO UNMODIFIED DNA
(Segmentation polarity homeobox protein engrailed)
referenceFeldman et al. 'Acs 1 755 2006
sourceDrosophila melanogaster
experimentX-ray (resolution=1.90, R-factor=0.225)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes2hos_AB 2hot_AB
redundant complexes2hot_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKN

Estimated binding specificities ?

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# IC=5.228 IC/col=0.871 n_of_columns=6 specificity:   
A |   1  72  96   8   0  11
C |   8   8   0   8  96  69
G |   0   8   0   8   0   8
T |  87   8   0  72   0   8
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ENGRAILED
TAATTAPubMed2hos_A(1.21e-03), 2hot_A(3.57e-04)
TAATCCPubMed2hos_A(4.53e-11), 2hos_AB(6.43e-08), 2hot_AB(5.23e-08), ... (total=4)
CGCATCCCCPubMed2hos_A(1.05e-02)
TTAATTPubMed2hos_A(1.21e-03), 2hot_A(3.57e-04)
TAATNNPubMed2hos_A(1.21e-03), 2hot_A(3.57e-04)

Dendrogram of similar interfaces ?

matrix format
  
  --IAQCNAMG----   L                          +---1b72_A    
                                 +------------2 
  --VTKGNA--KA--   L             !            +---2lkx_A    
                         +-------4 
  QTVAQTNA------   L     !       !                 +8osb_E    
                         !       ! +---------------1 
  --NCICRG------   L   +-5       +-3               +4xrm_B    
                       ! !         ! 
  --IAQCNAYC----   L   ! !         +----------------3rkq_B    
                     --6 ! 
  --VTCCNAQA--RT   L   ! +------------------------8g87_X    
                       ! 
  --------YCFAKC       +-------------------------6pe2_B

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updated Fri Sep 13 16:21:40 2024