interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF DNMT3A-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES
(DNA CYTOSINE-5-METHYLTRANSFERASE 3A)
referenceZhang et al. Nature 554 387 2018
sourceHOMO SAPIENS
experimentX-ray (resolution=2.65, R-factor=0.192)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase 579;
multimeric complexes5yx2_AD 6brr_AD 6w89_AD 6w89_GJ 6w8b_AD 6w8b_HK 6w8d_AD 6w8j_AD
reference complex6w8b_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIVNPTRSNL

Estimated binding specificities ?

contactlogo
# IC=1.837 IC/col=0.306 n_of_columns=6 specificity:   
A |  19  34  49   0  14  38
C |  19  22  15  96  54  19
G |  39  20  15   0  14  19
T |  19  20  17   0  14  20
scan!

home
updated Thu Sep 12 22:32:32 2024