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structure nameCRYSTAL STRUCTURE OF DNMT3A-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES
(DNA CYTOSINE-5-METHYLTRANSFERASE 3A)
referenceZhang et al. Nature 554 387 2018
sourceHOMO SAPIENS
experimentX-ray (resolution=2.65, R-factor=0.192)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase 579;
multimeric complexes5yx2_AD 6brr_AD 6w89_AD 6w89_GJ 6w8b_AD 6w8b_HK 6w8d_AD 6w8j_AD
reference complex6w8b_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIVNPTRSNL

Estimated binding specificities ?

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# IC=5.009 IC/col=0.835 n_of_columns=6 specificity:   
A |   0  38  90   0   0  53
C |   5  16   5  96  96  16
G |  86  21   0   0   0   6
T |   5  21   1   0   0  21
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updated Sat Aug 2 10:07:10 2025