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structure nameCRYSTAL STRUCTURE OF DNMT3A-DNMT3L IN COMPLEX WITH SINGLE CPG- CONTAINING DNA
(DNA CYTOSINE-5-METHYLTRANSFERASE 3A)
referenceZhang et al. Nature 554 387 2018
sourceHOMO SAPIENS
experimentX-ray (resolution=3.10, R-factor=0.213)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase 579;
multimeric complexes5yx2_AD 6brr_AD 6w89_AD 6w89_GJ 6w8b_AD 6w8b_HK 6w8d_AD 6w8j_AD
reference complex6w8b_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIVNPTRSNL

Estimated binding specificities ?

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# IC=5.807 IC/col=0.968 n_of_columns=6 specificity:   
A |  13  96   0   0   0  54
C |  13   0   0  96  96  13
G |  57   0  96   0   0  16
T |  13   0   0   0   0  13
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updated Thu Sep 12 23:19:55 2024