interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CGA DNA
referenceAnteneh et al. 'Nat 11 2294 2020
experimentX-ray (resolution=2.50, R-factor=0.197)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase 541;
multimeric complexes5yx2_AD 6brr_AD 6w89_AD 6w89_GJ 6w8b_AD 6w8b_HK 6w8d_AD 6w8j_AD
reference complex6w8b_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIVPRTRSNQ

Estimated binding specificities ?

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# IC=4.434 IC/col=0.887 n_of_columns=5 specificity:   
A |  13  54   0   0   0
C |  13  13   0  96  96
G |  54  13   0   0   0
T |  16  16  96   0   0
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updated Fri Sep 13 02:49:06 2024