interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF DNMT3A IN COMPLEX WITH CGA DNA
referenceAnteneh et al. 'Nat 11 2294 2020
experimentX-ray (resolution=2.40, R-factor=0.212)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase 579;
multimeric complexes5yx2_AD 6brr_AD 6pa7_ABCDEFGHKP 6w89_AD 6w89_GJ 6w8b_AD 6w8b_HK 6w8d_AD 6w8j_AD 8u5h_IJKMOQRS
reference complex6pa7_K
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIVPTRSNQ

Estimated binding specificities ?

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# IC=4.887 IC/col=0.977 n_of_columns=5 specificity:   
A |  19  76   0   0   0
C |  19  20   0  96  96
G |  38   0   0   0   0
T |  20   0  96   0   0
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updated Fri Jan 9 11:01:30 2026