7jn3_E : 3D-footprint complex

structure name	CRYO-EM STRUCTURE OF ROUS SARCOMA VIRUS CLEAVED SYNAPTIC COMPLEX (CSC) WITH HIV-1 INTEGRASE STRAND TRANSFER INHIBITOR MK-2048 (INTEGRASE)
source	ROUS SARCOMA VIRUS (STRAIN SCHMIDT-RUPPIN A) / ROUS SARCOMA VIRUS (STRAIN SCHMIDT-RUPPIN A)
experiment	NMR
structural superfamily	Ribonuclease H-like;DNA-binding domain of retroviral integrase;N-terminal Zn binding domain of HIV integrase;
sequence family	Integrase core domain; Integrase DNA binding domain; Integrase Zinc binding domain;
multimeric complexes	5ejk_ABG 5ejk_CE 7jn3_EF 7ku7_AB 7kui_EF
redundant complexes	5ejk_A 7ku7_G 7kui_B 8e14_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7jn3_E interface=51,76,151,154,157,158,161,203,244,246, plreakdlhtalhigpralskacnismqqarevvqtcphcnsapaleagvNprglgplqiwqtdftleprmaprsWlavtvdtassaivvtqhgrvtsvavqhhwataiavlgrpkaiktdngscftskstrewlarwgiahttgipgnsQgqAmvERanRllkdkirvlaegdgfmkriptskqgellakamyalnhfergEntktpiqkhwrptvltegppvkirietgewekgwnvlvwgRgYaavknrdtdkviwvpsrkvkpdi
interface signature	NWQAERRERY

Estimated binding specificities ?

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# IC=5.766 IC/col=0.961 n_of_columns=6

specificity:

A |  13   0   0   0   0  13
C |  13   0   0   0   0  16
G |  16  96   0   0  96  13
T |  54   0  96  96   0  54

scan!

Dendrogram of similar interfaces ?

matrix format

  
  VTPT------PAQAAGEARCQGRG--------   L                      +----------3jca_E    
                                                +-----------1 
  ----KTQT--PAQGAGECRGQG----------   L   +------2           +----------7u32_A    
                                         !      ! 
  ----------------------RAYACAPAWA     --3      +----------------------3jca_H    
                                         ! 
  --------RA----------------------       +-----------------------------7k78_E

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updated Sat Sep 14 02:38:27 2024