9foy_A : 3D-footprint complex

structure name	TERNARY COMPLEX OF A MYCOBACTERIUM TUBERCULOSIS DNA GYRASE CORE FUSION WITH DNA AND THE INHIBITOR AMK32B
reference	Mitchenall et al. 'To ? ? ?
experiment	X-ray (resolution=2.80, R-factor=0.281)
structural superfamily	Type II DNA topoisomerase;
sequence family	DNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 9foy_A interface=52,54,261,269,321,411, alvrrkglpgkladcrstdprkselyvvegdsaggsaksgrdsmfqailplRgKiinvekaridrvlkntevqaiitalgtgihdefdigklryhkivlmadadvdgqhistllltllfrfmrplienghvflaqpplyklkwqrsdpefaysdrerdglleaglkagkkinkedgiqrykglgemdakelwettmdpsvrvlrqvtlddaaaadelfsilmgedvdarrsfitrnakdvrflriepvdieqemqrsyidYamsvivgRalpevrdglkpvhrrvlyamfdsgfrpdrshaksarsvaetmgnyhphgdaSiydslvrmaqpwslryplvdgqgnfgspgndppaamrytearltplamemlreideetvdfipnydgrvqeptvlpsrfpnllangsggIavgmatnipphnlreladavfwalenhdadeeetlaavmgrvkgpdfptaglivgsqgtadayktgrgsirmrgvveveedsrgrtslvitelpyqvnhdnfitsiaeqvrdgklagisniedqssdrvglrivieikrdavakvvinnlykhtqlqtsfganmlaivdgvprtlrldqliryyvdhqldvivrrttyrlrkanerahilrglvkaldaldevialirasetvdiaraglielldideiqaqaildmqlrrlaalerqriiddlakieaeiadledilakperqrgivrdelaeivdrhgddrrtriia
interface signature	RKYRSI

Estimated binding specificities ?

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# IC=3.598 IC/col=0.514 n_of_columns=7

specificity:

A |  56  24   8  16  24   0   0
C |  16  24  56   0  24  96   0
G |   8  24  16  24  24   0  96
T |  16  24  16  56  24   0   0

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Dendrogram of similar interfaces ?

matrix format

  
  --KA------SA------------RGIG----------               +-----------------------------2xcr_U    
                                                     +-1 
  ----RC----ST--------------IA----------           +-2 +-----------------------------3ksb_B    
                                                   ! ! 
  KTKT----------------------------------         +-3 +-----------------------------7z9c_D    
                                                 ! ! 
  ------------NASTRG--STLT--------------   L   +-4 +-----------------------------7cby_C    
                                               ! ! 
  ------DCAG--TTRG--RG----RA------------   L --5 +-----------------------------5h3r_A    
                                               ! 
  ----------------------------NTATATSTRG   L   +-----------------------------1dh3_C

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updated Wed Dec 18 20:14:42 2024