interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF FOXP2 BOUND SPECIFICALLY TO DNA.
(Forkhead box protein P2)
referenceStroud et al. Structure 14 159 2006
sourceHomo sapiens
experimentX-ray (resolution=1.90, R-factor=0.222)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
multimeric complexes2a07_IK
redundant complexes2as5
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRHSL

Estimated binding specificities ?

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# IC=3.142 IC/col=0.786 n_of_columns=4 specificity:   
A |  13  54  96  96
C |  57  16   0   0
G |  13  13   0   0
T |  13  13   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------------------------NAST--RGHT----ST------------   L                                              +--3g73_A    
                                                                                   +------------------------4 
  ----------------------------NAST--RGHTNT--STLT----------   L                     !                        !  +7fj2_B    
                                                                                   !                        +--1 
  --------------------------QTNAST--RGNT--STLA------------   L                     !                           +2hdc_A    
                                                                                +-13  
  ------------------------KT----RGAT--RGYA----------------   L                  !  !                  +---------4iri_A    
                                                                                !  !  +---------------7 
  ------------------------------NT--RGCT----NGST----------   L                  !  !  !               +---------1if1_B    
                                                                             +-16  +-12  
  ------------------------KT----RG----RGYA----------------   L               !  !     !                 +-------1dux_F    
                                                                             !  !     +-----------------6 
  ----------------------------RTNT--RGSTAT----RT----------                +-17  !                       +-------1t2k_B    
                                                                          !  !  !  
  --RGRTKG----------------------------------------YGKC----   L            !  !  +-----------------------------6lui_A    
                                                                          !  !  
  ------------TC--STKTPTTT--FT------------------------RT--                !  +-----------------------------4ass_H    
                                                                          !  
  ----------------------SA--------------------------------                !                     +----------3l4j_A    
                                                                       +-18  +------------------8 
  ----------------------SA--------------------------------   L         !  !  !                  !   +------5npk_d    
                                                                       !  !  !                  +---5 
  ----------------------SG--------------------------------             !  !  !                      !     +5iwi_C    
                                                                       !  !  !                      +-----2 
  ----------------------ST--------------------------------             !  !  !                            +3ksb_B    
                                                                       !  +-15  
  MG----------------TGQAAT----SA------RG------------------   L         !     !                            +-2p5l_D    
                                                                       !     !      +---------------------3 
  --------DT--------------RGRCTT----KT----------RT--------   L      +-19     !      !                     +-2o9l_A    
                                                                    !  !     !  +--11  
  --------------------TTHT----KG--------------------------   L      !  !     !  !   !       +---------------7b0c_A    
                                                                    !  !     !  !   +------10  
  ----------SG--QG--YCNC----------------------------------          !  !     +-14           +---------------2ve9_C    
                                                                    !  !        !  
  ----------------NG----RGRG--YC--------------------------   L   +-20  !        !               +-----------1cf7_B    
                                                                 !  !  !        +---------------9 
  ------------------------------------YG------------------       !  !  !                        +-----------2heo_D    
                                                                 !  !  !  
  ------------------------------------------------------KG   L -21  !  +-----------------------------5xfp_B    
                                                                 !  !  
  ----------YC------KTHGSTQT--YTPT------------------------   L   !  +-----------------------------5x11_A    
                                                                 !  
  ----------------TT--RGRT--------------------------------   L   +-----------------------------2v1u_A    
                                                               

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updated Tue Dec 19 06:19:00 2023