interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF FOXP2 BOUND SPECIFICALLY TO DNA.
(Forkhead box protein P2)
referenceStroud et al. Structure 14 159 2006
sourceHomo sapiens
experimentX-ray (resolution=1.90, R-factor=0.222)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
multimeric complexes2a07_IK
redundant complexes2as5
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRHSL

Estimated binding specificities ?

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# IC=2.917 IC/col=0.729 n_of_columns=4 specificity:   
A |   0   0  12  12
C |  12   0  12  12
G |   0   0  12  60
T |  84  96  60  12
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------------------NAST--RGHT--STLT--------   L                          +------7cby_C    
                                                              +-----------1 
  ------ST----------NAST--RTHT--ST----------   L          +---2           +------3l2c_A    
                                                          !   ! 
  --------RGSTRT--STHG----------------RA----   L        +-3   +------------------3zpl_B    
                                                        ! ! 
  RT--LA--NTHGTTET--YTRG--------------------   L      +-4 +----------------------1f4k_B    
                                                      ! ! 
  --TT--------KATT--QTTG----LTRT----KA--FTYT   L   +--5 +------------------------2p7c_B    
                                                   !  ! 
  --------------KT----RGAT--RGNT------------   L --6  +--------------------------8smh_F    
                                                   ! 
  --------------------------YG--------------       +-----------------------------3eyi_B

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updated Tue Dec 17 22:36:10 2024