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structure nameHEPATOCYTE NUCLEAR FACTOR 1B BOUND TO DNA: MODY5 GENE PRODUCT
(Hepatocyte nuclear factor 1-beta)
referenceRha et al.
sourceHomo sapiens
experimentX-ray (resolution=3.20, R-factor=0.226)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyHepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain;
multimeric complexes2h8r_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNQSHSQTRYNK

Estimated binding specificities ?

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# IC=10.171 IC/col=0.782 n_of_columns=13 specificity:   
A |  11   0   0   0  11  62  59  24  24  96   0   6  96
C |  11   0   0   0  11  12  11  24  24   0   0   3   0
G |  12  96  96   0  62  11  15  24  24   0   0   3   0
T |  62   0   0  96  12  11  11  24  24   0  96  84   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----NTQASAHTSTQT------TTPG--RTYCNAATNAKG--   L              +--------------------------1ic8_B    
                                                              ! 
  ----------------------------RA--ITQTNAMG--   L           +--5                          +5zjt_E    
                                                           !  !                        +-1 
  ----STQATT------RG----------RARCVTCTNAQTRC   L           !  +------------------------3 +1au7_A    
                                                         +-6                           ! 
  ----------------------------RT--ITQCNAACRG   L         ! !                           +-6a8r_A    
                                                         ! ! 
  ----------------------------RTFTYAQTNAATRG   L       +-7 +-----------------------------6ryd_F    
                                                       ! ! 
  QT--STNTVTATSTQT--RTETTT------------------   L       ! !                         +---2r1j_L    
                                                       ! +-------------------------4 
  --AT--QAAT--SA----------------------------         +-8                           !   +4z5h_A    
                                                     ! !                           +---2 
  --STKCQAAT--SA----------------------------   L     ! !                               +3dnv_B    
                                                   +-9 ! 
  QT--TTQAQGST--ECQT----KC--RA--------------   L   ! ! +-----------------------------1per_L    
                                                 -10 ! 
  ----------------------------RA--ITQCNAMC--   L   ! +-----------------------------1b8i_A    
                                                   !  
  ----TTQA--LTSAET--------------------------   L   +-----------------------------2o4a_A    
                                                 

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updated Fri Sep 13 16:20:00 2024