2o61_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF NFKB, IRF7, IRF3 BOUND TO THE INTERFERON-B ENHANCER (TRANSCRIPTION FACTOR P65INTERFERON REGULATORY FACTOR...)
reference	'Cell(Cambridge,Mass.)' 129 1111 2007
source	HOMO SAPIENS
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	p53-like transcription factors;"Winged helix" DNA-binding domain;E set domains;
sequence family	Rel homology domain RHD; Interferon regulatory factor transcription f; IPT/TIG domain;
multimeric complexes	2o61_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2o61_A interface=15,17,18,20,21,23,169,200,312,356,357,359,360,363,364,427,429,465,466,468,469,473, gyveiieqpkqrgmRfRYkCEgRsagsipgerstdttkthptikingytgpgtvrislvtkdpphrphphelvgkdcrdgfyeaelcpdrcihsfqnlgiqcvkkrdleqaisqriqtnnnpfqvpieeqrgdydlnavrlcfqvtvrdpsgrplrlppvlshpifdnRapntaelkicrvnrnsgsclggdeifllcdKvqkedievyftgpgweargsfsqadvhrqvaivfrtppyadpslqapvrvsmqlrrpsdrelsepmefqylpdaaprvlfgewllgeissgcyeglqwldeartcfrvpwkHfarkdlseadarifkawavargrwppssrpppeaetaeragwkTNfRCalRStrrfvmlrdnsgdpadqhkvyalsgslssdslpwlvsqldlgqlegvawvnksrtrfripwkHgLrqdaqqedfgifqawaeatgayvpgrdkpdlptwkRNfRSalnRkeglrlaedrskdphdphkiyefvn
interface signature	RRYCERRKHTNRCRSHLRNRSR

Estimated binding specificities ?

readout + contact

# IC=16.983 IC/col=0.586 n_of_columns=29

specificity:

A |  12  96   0   0  96  90  24  24  24  24  24  24  24  24  24   0   1  84  93  24  24   1   0   1  15   0  24  24   4
C |   9   0   0   0   0   4  24  24  24  24  24  24  24  24  24   0   4  11   1  24  24  13  96   4  63  96  24  24   1
G |  72   0  96  96   0   1  24  24  24  24  24  24  24  24  24   0   1   0   1  24  24  15   0   1  15   0  24  24  82
T |   3   0   0   0   0   1  24  24  24  24  24  24  24  24  24  96  90   1   1  24  24  67   0  90   3   0  24  24   9

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RGRGYTCTECRT----------------------   L       +-----------------------------1gji_A    
                                               ! 
  --------------ECKT--RGAT--RGHT--RA   L     +-3                          +---4mhg_A    
                                             ! !                        +-1 
  ----------------KT--RG----RGYT----   L     ! +------------------------2 +---4bqa_A    
                                           +-4                          ! 
  ----------------KT--RG----RGYA----   L   ! !                          +----4l18_B    
                                         --5 ! 
  ------------------NAST--RGHT--ST--   L   ! +-----------------------------2uzk_A    
                                           ! 
  ------------ST----NAST--RTHT--ST--   L   +-----------------------------3l2c_A

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updated Fri Sep 13 16:32:37 2024