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legend  pdf

structure nameCRYSTAL STRUCTURE OF ARISTALESS AND CLAWLESS HOMEODOMAINS BOUND TO DNA
(HOMEOBOX PROTEIN ARISTALESS)
referenceMiyazono et al. 'Embo 29 1613 2010
sourceDROSOPHILA MELANOGASTER
experimentX-ray (resolution=2.70, R-factor=0.234)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes3a01_AB 3a01_EF
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRQVQN

Estimated binding specificities ?

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# IC=5.300 IC/col=0.663 n_of_columns=8 specificity:   
A |   0  11  96  96  24  24  67  67
C |   0   9   0   0  24  24   9   9
G |   0   9   0   0  24  24   9  11
T |  96  67   0   0  24  24  11   9
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: aristaless
TAATTAAPubMed3a01_F(1.69e-04), 3a01_AB(5.68e-10)

Dendrogram of similar interfaces ?

matrix format
  
  KGRT------------IAQCNAYA--RT   L                                     +1nk2_P    
                                                 +---------------------1 
  RCRT------------NT--NAITRG--                   !                     +5zjt_B    
                                           +-----5 
  --------------RCVACTNAQA----   L         !     !             +--------7xrc_C    
                                           !     +-------------3 
  --RT----STVC--KGDCRG--------   L       +-6                   +--------1w0t_A    
                                         ! ! 
  RTRT------------IAKGNA------   L       ! !            +---------------6m3d_C    
                                         ! +------------4 
  --RT----------FTYAQTNAATRG--   L     +-7              !          +----6ryd_F    
                                       ! !              +----------2 
  --------------RTVAITNAMCRG--   L     ! !                         +----1yrn_A    
                                     +-8 ! 
  --RA------------YAQTNAAARG--   L   ! ! +-----------------------------6wig_A    
                                   --9 ! 
  ----QGYC--------------------       ! +-----------------------------6u7t_A    
                                     ! 
  ------STRGQTQAST------------   L   +-----------------------------7t8k_B    
                                   

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updated Thu Dec 22 18:47:33 2022