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structure nameSTRUCTURE OF MYCOBACTERIUM SMEGMATIS HELICASE LHR BOUND TO SSDNA AND AMP-PNP
(ATP-dependent DNA helicase)
referenceJacewicz et al. 'Nucleic 46 442 2018
sourceMycobacterium smegmatis
experimentX-ray (resolution=2.80, R-factor=0.199)
structural superfamilyP-loop containing nucleoside triphosphate hydrolases;
sequence familyDEAD/H associated; DEAD/DEAH box helicase; Helicase conserved Cterminal domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRSPHRVTIPRWDSRASF

Estimated binding specificities ?

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# IC=10.793 IC/col=0.981 n_of_columns=11 specificity:   
A |  45   0  24   0   0   0   0   0   7   0   4
C |  16  96  24   0   0  96   0   0  74   0   7
G |  16   0  24   0  96   0   0  96   8  96  81
T |  19   0  24  96   0   0  96   0   7   0   4
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------------------RT--SCPGHC----------------------------------RGVGTGITPTRCWTDCSCRCAASCFT   L                                         +---------------5v9x_A    
                                                                                                                               +-------2 
  ----DC----------------NT----------------------------------------------------------------                                  +--3       +---------------6znp_A    
                                                                                                                            !  ! 
  --RC--HC------------QT------------------------------------------------------------------                                +-4  +-----------------------6m6b_M    
                                                                                                                          ! ! 
  --------SG------WGRA--ICKC--HT----------------------------------------------------------                              +-5 +--------------------------7aud_E    
                                                                                                                        ! ! 
  ----------------------VCKC--------------------------------------------------------------                            +-6 +---------------------------4u7d_A    
                                                                                                                      ! ! 
  ----------------------ICKC--------------------------------------------------------------                            ! !                            +4o3m_A    
                                                                                                                    +-7 +----------------------------1 
  RG----------QC--------IC----------------------------------------------------------------   L                      ! !                              +5n8r_B    
                                                                                                                  +-8 ! 
  ----------RC----------------------------------------------------------------------------                        ! ! +-----------------------------1z63_A    
                                                                                                                +-9 ! 
  ------------------------------------QTNAST--RGHTNT--STLA--------------------------------   L                  ! ! +-----------------------------2hdc_A    
                                                                                                             +-10 ! 
  --------------------------------------------RC----YG--------KT--------------------------                   !  ! +-----------------------------2acj_B    
                                                                                                          +-11  !  
  ----QG------HCRT------------------------------------------------------------------------                !  !  +-----------------------------6gen_M    
                                                                                                       +-12  !  
  ----EG----------------------------------------------------------------------------------             !  !  +-----------------------------6iy2_O    
                                                                                                    +-13  !  
  --------------------------------------------------YGRG----------------------------------          !  !  +-----------------------------4wcg_A    
                                                                                                 +-14  !  
  ------------------------------------------NAST--RGHTNT--STLT----------------------------   L   !  !  +-----------------------------7fj2_B    
                                                                                               -15  !  
  ------------------------------------------NAST--RGHT----STLT----------------------------   L   !  +-----------------------------7cby_C    
                                                                                                 !  
  ------------------------------YAKTPTPG----YTRG------------------------------------------   L   +-----------------------------4mtd_D    
                                                                                               

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updated Fri Sep 13 20:36:47 2024