5n8r_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DROSOPHILIA DHX36 HELICASE IN COMPLEX WITH GAGCACTGC (CG9323, isoform A)
reference	Hai-Lei Guo et al. Structure 26 403 2018
source	Drosophila melanogaster
experiment	X-ray (resolution=2.20, R-factor=0.178)
structural superfamily	P-loop containing nucleoside triphosphate hydrolases;
sequence family	Helicase associated domain HA2; Domain of unknown function DUF1605; Helicase conserved Cterminal domain;
redundant complexes	5n8s_A 5n8u_B 5n8z_B 5n90_B 5n96_A 5n98_A 5n9a_A 5n9d_A 5n9e_B 5n9f_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5n8r_B interface=176,198,199,201,202,223,359,360,392,417,437,440,451,495,503,562,564,591,592,598,603,607,715,731,732,733, lgcnvsapsgvlervkelmedysrapdakfqqqfrhllsvnfeefvaetkernadldwvnpklderlqlelgqrqleenakkrlearkklptmkyaddiiqavrenqvilivgstgcgkttqvpqillddaisrgcasscriictqprrisaiaiaewvsyerceslgnsvgyqiRlesrkarerasitycttgvllQQlQSdplmhnlsvlildeihersvEtdllmgllkvilphrpdlkvilmsatvreqdfcdyfnncpmfriegvmfpvkmlyledvlsktnyefqpperrmkheamiepylrrirnsydsrvldklrlpesegcedidfiadlvyyicenepegailvflpgYDkisqlynildkpktskgqrwrdhmavfplhsLmqsgeqqavfrrppagqrkviistIiaetsvtiddvvyvinsgrTkaTnydietniqsLdevwvtkantqqrrgragrvrpgicynlfsraredrmddiptpEilrskleSiilslkllhiddpyrflqtlinapnpeaikmgvellkriealdqtgtltplgmhlaklPiDpqmgkmilmsalfccldpitsaaaalSFkspfySplgkEsrvDeikrrmarnmrsdhlmvhntiiayrdsryshaerdfcyknflssmtlqqlermknqfsellynykflassnckdaasnknsekipllraiigaglypnmahlrksrqRaihtmatddgrrvnfHPSsvnsgesgfdsayfvyfqrqkstdlflldstmvfpmaliifgdgveagvtqntpylcvaktyyfkcnretadvviqlrsnleklllkkalypapieengyekqlikaielllslderl
interface signature	RQQQSEYDLITTLESPDSFSEDRHPS

Estimated binding specificities ?

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# IC=8.431 IC/col=0.937 n_of_columns=9

specificity:

A |   0  96   0   0  54  24  13   0   0
C |   0   0   0  96  13  24  16   0  96
G |  96   0  96   0  13  24  13  96   0
T |   0   0   0   0  16  24  54   0   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RG------QCQCQCSC------YGDGLG--IC--TCLC------EASG--------PGDGSGFT--SGEADG----RGHAPASA   L                        +------5n8r_B    
                                                                                                    +-------------1 
  ----------------TA--HA------RA--VA--TATATA------------------------------------------   L     +----2             +------3kqh_B    
                                                                                               !    ! 
  ------------------RA----------IC----------KC----------------------------------------   L   +-3    +--------------------7aud_E    
                                                                                             ! ! 
  --STSTRT--------------------------------------------------------ET------STVT--------   L --4 +-------------------------8w0a_C    
                                                                                             ! 
  ------------------------------------------------YAQTTCQC----------------------------   L   +---------------------------5k5q_D

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updated Mon Jun 29 20:27:45 2026