5n8r_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DROSOPHILIA DHX36 HELICASE IN COMPLEX WITH GAGCACTGC (CG9323, isoform A)
reference	Hai-Lei Guo et al. Structure 26 403 2018
source	Drosophila melanogaster
experiment	X-ray (resolution=2.20, R-factor=0.178)
structural superfamily	P-loop containing nucleoside triphosphate hydrolases;
sequence family	Helicase associated domain HA2; Domain of unknown function DUF1605; Helicase conserved Cterminal domain;
redundant complexes	5n8s_A 5n8u_B 5n8z_B 5n90_B 5n96_A 5n98_A 5n9a_A 5n9d_A 5n9e_B 5n9f_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5n8r_B interface=176,198,199,201,202,223,359,360,392,417,437,440,451,495,503,562,564,591,592,598,603,607,715,731,732,733, lgcnvsapsgvlervkelmedysrapdakfqqqfrhllsvnfeefvaetkernadldwvnpklderlqlelgqrqleenakkrlearkklptmkyaddiiqavrenqvilivgstgcgkttqvpqillddaisrgcasscriictqprrisaiaiaewvsyerceslgnsvgyqiRlesrkarerasitycttgvllQQlQSdplmhnlsvlildeihersvEtdllmgllkvilphrpdlkvilmsatvreqdfcdyfnncpmfriegvmfpvkmlyledvlsktnyefqpperrmkheamiepylrrirnsydsrvldklrlpesegcedidfiadlvyyicenepegailvflpgYDkisqlynildkpktskgqrwrdhmavfplhsLmqsgeqqavfrrppagqrkviistIiaetsvtiddvvyvinsgrTkaTnydietniqsLdevwvtkantqqrrgragrvrpgicynlfsraredrmddiptpEilrskleSiilslkllhiddpyrflqtlinapnpeaikmgvellkriealdqtgtltplgmhlaklPiDpqmgkmilmsalfccldpitsaaaalSFkspfySplgkEsrvDeikrrmarnmrsdhlmvhntiiayrdsryshaerdfcyknflssmtlqqlermknqfsellynykflassnckdaasnknsekipllraiigaglypnmahlrksrqRaihtmatddgrrvnfHPSsvnsgesgfdsayfvyfqrqkstdlflldstmvfpmaliifgdgveagvtqntpylcvaktyyfkcnretadvviqlrsnleklllkkalypapieengyekqlikaielllslderl
interface signature	RQQQSEYDLITTLESPDSFSEDRHPS

Estimated binding specificities ?

contact

# IC=8.472 IC/col=0.941 n_of_columns=9

specificity:

A |   0  96   0   0  54  24  13   0   0
C |   0   0   0  96  13  24  13   0  96
G |  96   0  96   0  16  24  13  96   0
T |   0   0   0   0  13  24  57   0   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --RG----QCQCQCSC--------YGDGLGIC--TCLC----------EASG--------------PGDGSGFT----SGEADG------------RGHAPASA----   L                                      +--5n8r_B    
                                                                                                                                      +-----------------1 
  --RT--------------QT----WT--LT--KTTTMT------------ETQT------------PT--STFTKT--ITETDT--------------HT--KTMTYT                        !                 +--5vhe_A    
                                                                                                                                 +----3 
  RA--YTEC--------KGRC----------PA------YCSAKTRT------------------------------EA------RTRATAEGWANG------------                   !    !     +--------------2p6r_A    
                                                                                                                               +-4    +-----2 
  ----------HA------------------NT----------------------------------------------------------------------------                 ! !          +--------------6znp_A    
                                                                                                                             +-5 ! 
  --------------------RA--------IC--------------KC------------------------------------------------------------               ! ! +-------------------------7aud_E    
                                                                                                                           +-6 ! 
  ----------------------QT------------------------------------------------------------------------------------             ! ! +---------------------------6m6b_M    
                                                                                                                         +-7 ! 
  ------------------------------VC--------------KC------------------------------------------------------------           ! ! +---------------------------4u7d_A    
                                                                                                                       +-8 ! 
  --------------------RG------------------------RG------------------------------------------------------------   L     ! ! +----------------------------6crm_A    
                                                                                                                     +-9 ! 
  ------------------------------------------------------SGQGYCNC----------------------------------------------       ! ! +-----------------------------2ve9_C    
                                                                                                                   -10 ! 
  --------RC--------------------------------------------------------------------------------------------------       ! +-----------------------------1z63_A    
                                                                                                                     !  
  ----------------------------------------------------------YAQTTCQC------------------------------------------   L   +-----------------------------5k5q_D

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updated Fri Sep 13 20:05:45 2024