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legend  pdf

structure nameSTRUCTURAL AND DNA BINDING STUDIES OF THE TRANSCRIPTIONAL REPRESSOR RV2506 (BKAR) FROM MYCOBACTERIUM TUBERCULOSIS SUPPORTS A ROLE IN L- LEUCINE CATABOLISM
(Probable transcriptional regulatory protein Probably TetR-family)
referencePritchard et al. 'To ? ? ?
sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
experimentX-ray (resolution=3.15, R-factor=0.268)
structural superfamilyHomeodomain-like;Tetracyclin repressor-like, C-terminal domain;
sequence familyBacterial regulatory proteins, tetR family;
multimeric complexes6yl2_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signaturePYR

Estimated binding specificities ?

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# IC=3.968 IC/col=0.661 n_of_columns=6 specificity:   
A |   9   9  67  24   0   0
C |   9  11   9  24  96  96
G |  11   9  11  24   0   0
T |  67  67   9  24   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------PT--YTRG   L                                  +-6yl2_A    
                                        +---------------1 
  TA--AT----LCFGHA                      !               +-4i6z_B    
                                    +---5 
  ----TCKGAG--YTHA                  !   !   +-------------5k7z_A    
                                    !   +---4 
  ----TGKG----YCFA   L              !       +-------------4pxi_B    
                                    ! 
  ----ATYA--LTYTFT   L            +-8               +-----6en8_C    
                                  ! !   +-----------3 
  MTRGTGPT--AT----   L            ! !   !           +-----5yej_B    
                                  ! ! +-6 
  --PT------------   L            ! ! ! !              +--6c31_A    
                               +--9 +-7 +--------------2 
  LC--RTPTPTSTYT--   L         !  !   !                +--6nsn_B    
                               !  !   ! 
  LTRG--PTAC--YT--   L      +-10  !   +-------------------3lsr_A    
                            !  !  ! 
  ----SCKGSG--IGYC   L      !  !  +----------------------2yvh_A    
                         +-11  !  
  TG--RTQAATSCYAYG   L   !  !  +-------------------------6gy3_A    
                       -12  !  
  ------KG----YT--       !  +---------------------------6wpa_A    
                         !  
  VTRGAT----QTHTHT   L   +----------------------------5vl9_A    
                       

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updated Wed Dec 18 07:04:47 2024