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structure nameSTRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP
(PROTEIN TRANSCRIPTION FACTOR E2F-4)
referencePavletich et al. 'Genes 13 666 1999
sourceHOMO SAPIENS
experimentX-ray (resolution=2.60, R-factor=?)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyE2F/DP family wingedhelix DNAbinding domai;
multimeric complexes1cf7_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRRY

Estimated binding specificities ?

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# IC=7.373 IC/col=0.922 n_of_columns=8 specificity:   
A |  12   0  14   6   0   0   0   0
C |  12   6  64  12  89   0  96   0
G |  12   1   6  72   6  96   0  96
T |  60  89  12   6   1   0   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: E2F-4
CTCCGCGCPubMed1cf7_A(1.86e-04), 1cf7_AB(1.66e-04)

Dendrogram of similar interfaces ?

matrix format
  
  RC----------------------RGRG--YC------------------------   L                                                            +--1cf7_A    
                                                                                                            +-------------2 
  ----------------------RC------RC------------------------                                                  !             +--6wfq_C    
                                                                                                          +-8 
  --------------------------------------YG----------------                                                ! !                +2heo_D    
                                                                                                          ! ! +--------------1 
  ------------LT--------RTSGTG--QTRG----------------------   L                                          +-9 +-7              +2xro_E    
                                                                                                        ! !   ! 
  ------------------------NT--TCTA--------------------RT--   L                                          ! !   +--------------5zux_A    
                                                                                                     +-11 ! 
  ----------------------RCTT----TTHT--LA------------------   L                                       !  ! +------------------7e1b_B    
                                                                                                  +-12  !  
  --------------SGQG----YCNC------------------------------                                        !  !  +--------------------2ve9_C    
                                                                                               +-13  !  
  ------------------------TTHT----KG--------------RC------   L                                 !  !  +---------------------7b0c_A    
                                                                                            +-14  !  
  ------RGRTKG------------------------------------YG------   L                              !  !  +----------------------6lui_A    
                                                                                         +-15  !  
  ------------------------NTVC--ECSTYT--STYC--------RA----   L                           !  !  +-----------------------5ed4_A    
                                                                                      +-16  !  
  --------------TC----STKTPTTT--FT--------------------RT--                            !  !  +------------------------4ass_H    
                                                                                   +-17  !  
  --------------------DCLT--AG--TTRG------RG------------RA   L                     !  !  +------------------------5h3r_A    
                                                                                +-18  !  
  ----KC----------------MGSGTT--TTYC----------------------   L                  !  !  +-------------------------5f7q_C    
                                                                                !  !  
  --------------------------SA----------------------------                      !  +-------------------------3l4j_A    
                                                                             +-19  
  --------------------------SA----------------------------   L               !  !                      +-----5npk_d    
                                                                             !  !                    +-3 
  ------------------------QAAG----------------------------   L               !  +--------------------5 +-----5zen_A    
                                                                          +-20                       ! 
  --------------------------SG----------------------------                !  !                       +-----5iwi_C    
                                                                          !  !  
  ------------------NG----RGRG--YC------------------------   L         +-21  !              +------------1cf7_B    
                                                                       !  !  +--------------6 
  ------------------------------NAST--RGHT----ST----------   L         !  !                 +------------3g73_A    
                                                                       !  !  
  --------------------STRGECTA--NGKG----------------------   L      +-22  +----------------------------3mzh_A    
                                                                    !  !  
  --KC------------------YAQTTC----QC----------------------   L      !  !                      +-----5k5q_D    
                                                                    !  !        +-------------4 
  --------------------------QTNAST--RGHTNT--STLA----RT----   L   +-23  +-------10             +-----2hdc_A    
                                                                 !  !           !  
  ------------------------------NAST--RGHTNT--STLT--------   L   !  !           +-------------------7fj2_B    
                                                               -24  !  
  ------------------------DCKT----RG----RGYA--------------   L   !  +----------------------------1dux_F    
                                                                 !  
  ------------------------------KGSA----QA----------------   L   +----------------------------6j5b_C    
                                                               

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updated Fri Sep 13 15:29:13 2024