interface graph thumbnail
legend  pdf

structure nameSTRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP
(PROTEIN TRANSCRIPTION FACTOR E2F-4)
referencePavletich et al. 'Genes 13 666 1999
sourceHOMO SAPIENS
experimentX-ray (resolution=2.60, R-factor=?)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyE2F/DP family wingedhelix DNAbinding domai;
multimeric complexes1cf7_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRRY

Estimated binding specificities ?

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# IC=7.415 IC/col=0.927 n_of_columns=8 specificity:   
A |  12   6  12   6   0   0   0   0
C |  12  12  54   6  90   0  96   0
G |   6   0  18  84   6  96   0  96
T |  66  78  12   0   0   0   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: E2F-4
CTCCGCGCPubMed1cf7_A(1.86e-04), 1cf7_AB(1.66e-04)

Dendrogram of similar interfaces ?

matrix format
  
  ------------NGSA--RGHGSC--------   L             +-----------------------------6el8_A    
                                                 +-1 
  --------ST--TAQC----------------             +-2 +-----------------------------8b4b_W    
                                               ! ! 
  ------HT----RTITYT--------------   L       +-3 +-----------------------------4kfc_B    
                                             ! ! 
  ----RGTC--DCVA----RGRC----RC----   L     +-4 +-----------------------------8hih_Q    
                                           ! ! 
  --STRGQTQA--ST----------HG--KT--   L   +-5 +-----------------------------7t8k_B    
                                         ! ! 
  RA------------------------------   L --6 +-----------------------------8ac8_C    
                                         ! 
  --NTHG--RT--YTPT--------------RT   L   +-----------------------------6qil_A    
                                       

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updated Sun Aug 3 05:25:00 2025