1xpx_A : 3D-footprint complex

structure name	STRUCTURAL BASIS OF PROSPERO-DNA INTERACTION; IMPLICATIONS FOR TRANSCRIPTION REGULATION IN DEVELOPING CELLS (Protein prospero)
reference	Matthews et al.
source	Drosophila melanogaster
experiment	X-ray (resolution=2.80, R-factor=0.217)
structural superfamily	Homeodomain-like;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1xpx_A interface=46,50,53, sstltpmhlrkaklmffwvrypssavlkmyfpdikfnknntaqlvKwfsNfrEfyyiqmekyarqavteselyrvlnlhynrnnhievpqnfrfvvestlreffraiqggkdteqswkksiykiisrmddpvpeyfkspnfleq
interface signature	KNE

Estimated binding specificities ?

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# IC=3.101 IC/col=0.775 n_of_columns=4

specificity:

A |  13  96   0  13
C |  54   0   0  13
G |  13   0  96  54
T |  16   0   0  16

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ----KG--NA--EC--   L                            +-----------------1xpx_A    
                                            +-----1 
  --NCITNARGRG----   L                    +-2     +-----------------6fqq_E    
                                          ! ! 
  --ITQTNAMG------   L                  +-3 +-----------------------5zjt_E    
                                        ! ! 
  --IAKGNA--------   L                +-4 +-------------------------2hdd_A    
                                      ! ! 
  --IA--NA--------                  +-5 +--------------------------4qtr_D    
                                    ! ! 
  --NT--NA--RG----   L            +-6 +---------------------------1b8i_B    
                                  ! ! 
  KTIAQCNA------RT   L          +-7 +---------------------------1ig7_A    
                                ! ! 
  KGSAQA----------   L        +-8 +---------------------------6j5b_C    
                              ! ! 
  --ITQCNAACRG----   L      +-9 +----------------------------6a8r_A    
                            ! ! 
  ----NT--NA--ITRG       +-10 +----------------------------5zjt_B    
                         !  !  
  --NT--NAIARG----   L -11  +----------------------------1b72_B    
                         !  
  KGDCRG----------   L   +----------------------------1w0t_A

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updated Tue Dec 17 22:29:59 2024