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structure nameSTRUCTURE OF THE PROGESTERONE RECEPTOR-DNA COMPLEX
(PROGESTERONE RECEPTOR)
referenceChurchill et al. Mol.Endocrinol. 20 3042 2006
sourceHOMO SAPIENS
experimentX-ray (resolution=2.50, R-factor=0.203)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes2c7a_AB 4ond_AB 4ond_EF 4oor_AB 4oor_EF 4ov7_AB 4ov7_EF 5cbz_AB 5cbz_EF 5cc0_AB
reference complex5cbz_E
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVRR

Estimated binding specificities ?

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# IC=4.337 IC/col=0.620 n_of_columns=7 specificity:   
A |  12  24   0  24  48   0  96
C |  48  24   0  24  12  96   0
G |  12  24  96  24  24   0   0
T |  24  24   0  24  12   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------KGVT--RG------RC--   L              +2c7a_A    
                                            +-4 
  --HGECAGKGAAKGRT----RT----   L            ! +1lo1_A    
                                         +-12  
  ----ET--KGAT--RG----------   L         !  !  +1lat_B    
                                         !  +--1 
  ----EC--KG--KGRG----------   L         !     +2ff0_A    
                                      +-14  
  ----EA--KG--KTRG----------   L      !  !    +2han_A    
                                      !  !  +-5 
  ----DA--KG--RTRG----------   L      !  !  ! ! +3cbb_B    
                                      !  !  ! +-2 
  CA--EC--KG--KGRG----------   L      !  +-10   +1cit_A    
                                      !     !  
  ----EC--KG--RGRG----------   L      !     ! +1dsz_A    
                                   +-15     +-3 
  ----EC--KG--KGRG----------   L   !  !       +2a66_A    
                                   !  !  
  --------KGVT--RG--------KC   L   !  !         +-1r4o_A    
                                   !  !       +-7 
  ----EA--KG--RTRT--RT------   L   !  !     +-9 +-2han_B    
                                   !  !     ! ! 
  ----EC--KG--KGRG----------   L   !  !  +-11 +-1dsz_B    
                                 -16  !  !  !  
  ----EC--KG--RGRG----------   L   !  +-13  +-2nll_B    
                                   !     !  
  --HC----KGVT--RG------RT--   L   !     +--3g9m_B    
                                   !  
  --HT----KGVAKTRG----------   L   !    +1r4i_B    
                                   !  +-6 
  ----EC--KG--RGRGRT--------   L   +--8 +3e00_D    
                                      ! 
  ----EC--KGAGKGRG----------   L      +-1hcq_F

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updated Mon Dec 16 19:24:16 2024