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legend  pdf

structure nameRETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
(PROTEIN RETINOIC ACID RECEPTOR)
referenceRastinejad et al. Nature 375 203 1995
sourceHOMO SAPIENS
experimentX-ray (resolution=1.90, R-factor=0.206)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes2nll_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKKR

Estimated binding specificities ?

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# IC=4.046 IC/col=0.809 n_of_columns=5 specificity:   
A |   9   0   9   9  96
C |  11   0   9  69   0
G |  67  96   9   9   0
T |   9   0  69   9   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --ECKGAG--RG--   L                                 +4ond_A    
                                                 +---1 
  --ECKG--KGRG--   L                    +--------5   +2ff0_A    
                                        !        ! 
  --ECKG--KGRG--                +-------8        +---3dzy_A    
                                !       ! 
  ----KGVT--RG--                !       +------------5emp_A    
                                !  
  CAECKG--KGRG--   L            !                +----6l6q_B    
                                !       +--------6 
  ----KGVT--RG--   L   +-------11       !        +----2c7a_B    
                       !        !       ! 
  --EAKG--RTRTRT       !        !  +----9             +2han_B    
                       !        !  !    !    +--------2 
  --EAKG--RTRTRT       !        !  !    !    !        +4umm_E    
                       !        !  !    +----7 
  --ECKGAGKGRG--   L   !        !  !         !       +1hcq_E    
                     -12        +-10         +-------4 
  --ETKGAT--RG--   L   !           !                 ! +1lat_A    
                       !           !                 +-3 
  --ECKG--RGRG--   L   !           !                   +3dzy_D    
                       !           !  
  ----KAVA--RA--   L   !           +------------------5e69_A    
                       !  
  --ECKA--RGRG--   L   +-----------------------------4nqa_I    
                     

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updated Thu Dec 22 18:24:27 2022