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structure nameANCESTRAL STEROID RECEPTOR 2 DBD HELIX MUTANT - ERE DNA COMPLEX
(Ancestral SR2 Helix Mutant)
referenceOrtlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
sourcesynthetic construct
experimentX-ray (resolution=2.25, R-factor=0.188)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes2c7a_AB 4ond_AB 4ond_EF 4oor_AB 4oor_EF 4ov7_AB 4ov7_EF 5cbz_AB 5cbz_EF 5cc0_AB
reference complex5cbz_E
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKAR

Estimated binding specificities ?

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# IC=4.613 IC/col=0.769 n_of_columns=6 specificity:   
A |  68   6   4   6  11  96
C |  18   4   6   4  54   0
G |   4  86  82   4  18   0
T |   6   0   4  82  13   0
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updated Tue Dec 17 00:06:11 2024