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structure nameTWO-COMPONENT RESPONSE REGULATOR NARL/DNA COMPLEX: DNA BENDING FOUND IN A HIGH AFFINITY SITE
(NitrateNitrite Response Regulator Protein NARL)
referenceKaczor-Grzeskowiak et al. Nat.Struct.Biol. 9 771 2002
sourceEscherichia coli
experimentX-ray (resolution=2.12, R-factor=?)
structural superfamilyC-terminal effector domain of the bipartite response regulators;
sequence familyBacterial regulatory proteins, luxR fami; Sigma70, region 4;
multimeric complexes1je8_AB 1je8_EF 1zg1_AB 1zg1_EF 1zg5_AB 1zg5_EF
redundant complexes1zg1_A 1zg5_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSTKVHK

Estimated binding specificities ?

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# IC=2.081 IC/col=0.347 n_of_columns=6 specificity:   
A |   7  42  14   7  20  58
C |   7  18  70  74  29  13
G |   7  21   6   8  22  12
T |  75  15   6   7  25  13
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Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: NARL
TACTCCPubMed1zg1_EF(3.86e-04), 1zg5_EF(2.57e-03)
TACCATPubMed1je8_F(1.12e-03), 1zg5_B(3.41e-03), 1zg1_A(1.15e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----KGTCKGTCHT--   L                              +4wuh_B    
                                    +---------------1 
  TC--KTTCKGTCHTST   L              !               +7ve5_B    
                           +--------3 
  ----SCTAKTVCHTKG   L     !        !          +----1je8_F    
                         +-4        +----------2 
  --ITKGTASTSAQT--   L   ! !                   +----5w43_B    
                       --5 ! 
  TTRCECRTRCQT----   L   ! +------------------------7kuf_B    
                         ! 
  --------------YG       +-------------------------2heo_D    
                       

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updated Tue Dec 19 05:46:08 2023