interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1, RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
(PROTEIN C-ETS-1)
referenceShiina et al. J.Mol.Biol. 427 1655 2015
sourceHOMO SAPIENS
experimentX-ray (resolution=2.35, R-factor=0.249)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes1mdm_AB 2nny_AB 3mfk_AB 3wts_AC 3wtt_AC 3wtu_AC 3wtv_AC 3wtw_AC 3wtx_AC 3wty_AC
redundant complexes1mdm_B 2nny_A 3mfk_A 3ri4_D 3wtt_H 3wtu_C 3wtw_C 3wtx_C 3wtv 3wty
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRRY

Estimated binding specificities ?

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# IC=3.142 IC/col=0.786 n_of_columns=4 specificity:   
A |  13   0   0  13
C |  13  96  96  13
G |  13   0   0  16
T |  57   0   0  54
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------------KT--RG--RGYA------   L                                     +--3wts_C    
                                                           +-------------2 
  ------------KT--RG--RGYA------   L                       !             +--4lg0_B    
                                                         +-8 
  SG--------DCKT--RG--RGYA------   L                     ! !           +----3zp5_A    
                                                         ! +-----------3 
  ----------------TT--CT--NGKG--   L                   +-9             +----7oot_B    
                                                       ! ! 
  ------------KT--RGATRGYA------   L                   ! !       +---------4iri_A    
                                                       ! +-------5 
  --NC------------TT--CT--NGKG--   L                +-10         +---------7rh2_B    
                                                    !  !  
  ------------KT--RGATRGYT------   L                !  !           +------1awc_A    
                                                    !  !       +---4 
  ----------DCKT--RGSTRGYA------   L                !  +-------6   +------4bnc_A    
                                             +-----11          ! 
  ------------------NTCT--NGST--   L         !      !          +----------1if1_B    
                                             !      !  
  ----------DCKT--RGATRCYA------   L         !      !                  +5e8i_D    
                                          +-12      !      +-----------1 
  ----------DCKT--RG--RGYA----KA   L      !  !      +------7           +5jvt_A    
                                          !  !             ! 
  ----RC------------------------       +-13  !             +-----------7cow_T    
                                       !  !  !  
  ------------KT--RG--RAYA------   L   !  !  +-------------------------6vge_A    
                                     -14  !  
  ----------KG----ATNTCT----SC--   L   !  +----------------------------2irf_L    
                                       !  
  ------NGHTETKGRGQG--QT--------   L   +----------------------------4esj_A    
                                     

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updated Thu Dec 22 19:50:52 2022