2wbs_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE ZINC FINGER DOMAIN OF KLF4 BOUND TO ITS TARGET DNA (KRUEPPEL-LIKE FACTOR 4)
reference	Carstanjen et al. 'Cell.Mol.Life 68 3121 2011
source	MUS MUSCULUS
experiment	X-ray (resolution=1.70, R-factor=0.202)
structural superfamily	beta-beta-alpha zinc fingers;
sequence family	Zinc finger, C2H2 type;
redundant complexes	2wbu_A 4m9e_A 5ke6_A 5ke7_A 5ke8_A 5ke9_A 5kea_A 5keb_A 6vtx_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2wbs_A interface=47,49,50,53,75,76,77,78, tathtcdyagcgktytksshlkahlrthtgekpyhcdwdgcgwkfaRsDEltRhyrkhtghrpfqcqkcdrafsRSDHlalhmkrhf
interface signature	RDERRSDH

Estimated binding specificities ?

readout + contact

# IC=5.766 IC/col=0.961 n_of_columns=6

specificity:

A |  54   0   0   0   0  13
C |  16   0   0  96   0  54
G |  13  96  96   0  96  16
T |  13   0   0   0   0  13

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: KLF4
CACCC	PubMed	5ke6_A(4.06e-03), 6vtx_A(1.62e-06), 5ke9_A(1.01e-05)

Dendrogram of similar interfaces ?

matrix format

  
  RGSTYGYC----QCTGSTRGYT--               +-----------------------------4is1_C    
                                       +-2 
  ----HTHGRGTGTTACNA--KGRG   L       +-3 +-----------------------------1tf3_A    
                                     ! ! 
  --DGYCKGRG--QA--TC------   L     +-4 +-----------------------------5k5h_A    
                                   ! ! 
  ----HCHGRG--TAACNA--KGRG   L   +-5 +-----------------------------1tf6_A    
                                 ! ! 
  --CTSTQTLTITSTSTHT--RG--   L --6 +-----------------------------5v3j_F    
                                 ! 
  ----ETTG----YGST--------       !             +---------------6e94_A    
                                 +-------------1 
  --QA--TCRG--RGYCRT------   L                 +---------------7txc_E

home
updated Fri Sep 13 16:44:28 2024