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structure nameMOUSEZFP568-ZNF1-10 IN COMPLEX WITH DNA
(Zinc finger protein 568)
referencePatel et al. Cell 173 221 2018
sourceMus musculus
experimentX-ray (resolution=2.06, R-factor=0.194)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
redundant complexes5v3m_C 5wjq_D
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRSHRYDTCSQLISSHRRERCTTERRERSER

Estimated binding specificities ?

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# IC=27.893 IC/col=1.213 n_of_columns=23 specificity:   
A |   9   0   0   0   0   0   0  20  86   0  96   0   0   0  96  96  96  59  96   0   0   0   0
C |   9   0  96   0   0   0   0  76   1  96   0   0   0   0   0   0   0   9   0   0   0   0  96
G |  67  96   0  96   0  96  96   0   9   0   0  96  96   0   0   0   0  19   0  96  96  96   0
T |  11   0   0   0  96   0   0   0   0   0   0   0   0  96   0   0   0   9   0   0   0   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RGSGHGRGYADCTT------CT--STQTLTITST--STHTRG--RG--EA--RA------TTTGECRG--RG----ET------RGSCECRG   L              +------------------5v3j_F    
                                                                                                                ! 
  --------------------------------------------DCSCQG--KT--TTAT--SCSC----DC--SGATRARG--RGDCNA--   L           +--9      +-----------6ml4_A    
                                                                                                             !  ! +----4 
  DCYCKGRGQA----TC----RC--SCDCVT--------------------------------------------------------------   L           !  +-6    +-----------5k5i_A    
                                                                                                             !    ! 
  ----------------------------------------------------------QA----TCRG--RG--YCRT--------------   L           !    +----------------7txc_E    
                                                                                                             !  
  ------------------------------------SA--MT--VT--NA--RG--------ETTG----YG--ST----------------               !                     +--6e94_A    
                                                                                                          +-11            +--------2 
  DGYCKGRGQA----TC----RA--SCDCVT--------------------------------------------------------------   L        !  !            !        +--5k5h_A    
                                                                                                          !  !      +-----5 
  --------------------RGSTDTEGRG--RGSGDCHGTT--RGDAEG--RG--------------------------------------   L        !  !      !     !           +4x9j_A    
                                                                                                          !  !      !     +-----------1 
  --------------------------KG--------HTHGRGTGTTACNA--KGRG------------------------------------   L        !  !  +---8                 +1tf3_A    
                                                                                                          !  !  !   ! 
  ------------------------------------------FT--KAYT--------WT--WTSTET--FTVASGDC--SARG--------   L   +---12  !  !   !      +----------6jnm_A    
                                                                                                     !    !  +-10   +------3 
  ------------------------------RGST--YGYC----QCTGSTRGYT--------------------------------------       !    !     !          +----------4is1_C    
                                                                                                     !    !     !  
  ------------------QT--AG--KGRG--RG--DCKG----------------------------------------------------   L   !    !     +---------------------7n5w_A    
                                                                                                   -13    !  
  --------------------------------------YG----WTWTST--ET----FTVASGDCSART----------------------   L   !    !      +----------------6a57_A    
                                                                                                     !    +------7 
  NTSTNAVTQTSTSGKGRG--------------------------------------------------------------------------   L   !           +----------------6u9q_A    
                                                                                                     !  
  ------------------------------------TCSGRG--LTETYC--------NTYGQG----------------------------   L   +----------------------------6dfb_A    
                                                                                                   

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updated Fri Sep 13 20:34:51 2024