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structure nameTHE 3.5A CRYSTAL STRUCTURE OF THE CATALYTIC CORE (B'A' REGION) OF STAPHYLOCOCCUS AUREUS DNA GYRASE COMPLEXED WITH GSK299423 AND DNA
(DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A)
referenceEggleston et al. Nature 466 935 2010
sourceSTAPHYLOCOCCUS AUREUS
experimentX-ray (resolution=3.50, R-factor=0.210)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes2xcr_BD 2xcr_SU 2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5cdo_ABCD 5cdo_RSTU 5cdq_ABCD 5cdq_RSTU 5cdr_AB 5cdr_CD 5iwi_AB 5iwi_CD 5iwm_ABCD 5npk_bd 6fm4_BD 6fqm_ABCD 6fqm_abcd 6fqv_ABCD 6fqv_RSTU 6qtk_ABCD 6qtp_ABCD 6qx1_ABCD 7fvs_AB 7fvt_AB 7mvs_AB
reference complex5iwi_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKYRSEI

Estimated binding specificities ?

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# IC=2.714 IC/col=0.678 n_of_columns=4 specificity:   
A |   9   0   9  67
C |  69   0   9   9
G |   9  96   9   9
T |   9   0  69  11
scan!

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updated Thu Jan 8 20:46:44 2026