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structure nameTHE 2.1A CRYSTAL STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH GSK299423 AND DNA
(DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A)
referenceEggleston et al. Nature 466 935 2010
sourceSTAPHYLOCOCCUS AUREUS
experimentX-ray (resolution=2.10, R-factor=0.184)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5npk_bd 6fm4_BD 7fvs_AB 7fvt_AB 7mvs_AB
redundant complexes5cdo 4plb 5cdq 5cdp 2xct 5cdn 5cdr 5cdm 4bul 5bs3
reference complex5npk_d
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKYSESI

Estimated binding specificities ?

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# IC=6.806 IC/col=0.486 n_of_columns=14 specificity:   
A |   0   0   4  24  24  24  24  24  18  14   6  22   0   0
C |  96   0  25  24  24  24  24  24  41  60  61  13  96   0
G |   0  96   7  24  24  24  24  24  29  16   2  45   0  96
T |   0   0  60  24  24  24  24  24   8   6  27  16   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RGKT----------SAET------IC--------------   L                                +2xcs_B    
                                                                         +----4 
  --KT----RC----AT--------IC--RG----------   L                           !    ! +2xkk_C    
                                                                         !    +-3 
  --KA----RT----AAETRG----IC--RA----------   L                           !      +5eix_A    
                                                                     +---7 
  --KA--DC--------------ECIGSG------------   L                       !   !    +-4fm9_A    
                                                                     !   !  +-5 
  --KT----------SA------EGIGSC------------                           !   +--6 +-3l4j_A    
                                                        +------------8      ! 
  --KG----------AG--RT--ECIGAG------------              !            !      +--3qx3_B    
                                                        !            ! 
  ----YA--RT----SA--------IG--------------              !            !           +5cdp_C    
                                                    +---9            !         +-1 
  ----YT--------ST----RA--IG--------------          !   !            +---------2 +5bs8_A    
                                                    !   !                      ! 
  ------------STSA--RA----IA--------------       +-10   !                      +3rae_A    
                                                 !  !   ! 
  --KT------------------------------------       !  !   +----------------------5bs8_D    
                                               -11  !  
  ----------RCQG------SG------------------       !  +--------------------------4qlc_U    
                                                 !  
  ------------------------------NTATATSTRG   L   +----------------------------1dh3_C    
                                               

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updated Thu Sep 12 16:37:53 2024