| structure name | THE 2.1A CRYSTAL STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH GSK299423 AND DNA (DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A) |
| reference | Eggleston et al. Nature 466 935 2010 |
| source | STAPHYLOCOCCUS AUREUS |
| experiment | X-ray (resolution=2.10, R-factor=0.184) |
| structural superfamily | Type II DNA topoisomerase; |
| sequence family | DNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain; |
| redundant complexes | 5cdo 4plb 5cdq 5cdp 2xct 5cdn 5cdr 5cdm 4bul 5bs3 |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | RKYSESI |
Estimated binding specificities ?
| readout + contact |  |
A | 0 0 8 24 24 24 24 24 12 10 8 12 0 0 C | 96 0 32 24 24 24 24 24 58 70 56 12 96 0 G | 0 96 6 24 24 24 24 24 12 8 2 64 0 96 T | 0 0 50 24 24 24 24 24 14 8 30 8 0 0scan! |
Dendrogram of similar interfaces ?
matrix formatRGKT----------SAET------IC-------------- L +2xcs_B +----4 --KT----RC----AT--------IC--RG---------- L ! ! +2xkk_C ! +-3 --KA----RT----AAETRG----IC--RA---------- L ! +5eix_A +---7 --KA--DC--------------ECIGSG------------ L ! ! +-4fm9_A ! ! +-5 --KT----------SA------EGIGSC------------ ! +--6 +-3l4j_A +------------8 ! --KG----------AG--RT--ECIGAG------------ ! ! +--3qx3_B ! ! ----YA--RT----SA--------IG-------------- ! ! +5cdp_C +---9 ! +-1 ----YT--------ST----RA--IG-------------- ! ! +---------2 +5bs8_A ! ! ! ------------STSA--RA----IA-------------- +-10 ! +3rae_A ! ! ! --KT------------------------------------ ! ! +----------------------5bs8_D -11 ! ----------RCQG------SG------------------ ! +--------------------------4qlc_U ! ------------------------------NTATATSTRG L +----------------------------1dh3_C |
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updated Mon Dec 16 20:13:07 2024