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legend  pdf

structure nameNOVEL HYDROXYL TRICYCLICS (E.G. GSK966587) AS POTENT INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES
(DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A)
referenceRittenhouse et al.
sourceSTAPHYLOCOCCUS AUREUS
experimentX-ray (resolution=2.60, R-factor=0.145)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5npk_bd 6fm4_BD 7fvs_AB 7fvt_AB 7mvs_AB
reference complex5npk_d
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKYSSRRI

Estimated binding specificities ?

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# IC=3.142 IC/col=0.628 n_of_columns=5 specificity:   
A |   0   0  24  57  13
C |  96   0  24  13  16
G |   0  96  24  13  54
T |   0   0  24  13  13
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updated Thu Sep 12 18:51:41 2024