| structure name | NOVEL HYDROXYL TRICYCLICS (E.G. GSK966587) AS POTENT INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES (DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A) |
| reference | Rittenhouse et al. |
| source | STAPHYLOCOCCUS AUREUS |
| experiment | X-ray (resolution=2.60, R-factor=0.145) |
| structural superfamily | Type II DNA topoisomerase; |
| sequence family | DNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain; |
| multimeric complexes | 2xcr_BD 2xcr_SU 2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5cdo_ABCD 5cdo_RSTU 5cdq_ABCD 5cdq_RSTU 5cdr_AB 5cdr_CD 5iwi_AB 5iwi_CD 5iwm_ABCD 5npk_bd 6fm4_BD 6fqm_ABCD 6fqm_abcd 6fqv_ABCD 6fqv_RSTU 6qtk_ABCD 6qtp_ABCD 6qx1_ABCD 7fvs_AB 7fvt_AB 7mvs_AB |
| reference complex | 5iwi_C |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | KYSSRRI |
Estimated binding specificities ?
readout + contact |  |
A | 0 0 24 54 13 C | 96 0 24 13 13 G | 0 96 24 13 54 T | 0 0 24 16 16scan! |
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updated Thu Jan 8 23:55:14 2026