structure name | NOVEL HYDROXYL TRICYCLICS (E.G. GSK966587) AS POTENT INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES (DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A) |
reference | Rittenhouse et al. |
source | STAPHYLOCOCCUS AUREUS |
experiment | X-ray (resolution=2.60, R-factor=0.145) |
structural superfamily | Type II DNA topoisomerase; |
sequence family | DNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain; |
multimeric complexes | 2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5npk_bd 6fm4_BD 7fvs_AB 7fvt_AB 7mvs_AB |
reference complex | 5npk_d |
links to other resources | NAKB PDIdb DNAproDB |
protein sequence | |
interface signature | KYSSRRI |
Estimated binding specificities ?
readout + contact |
A | 0 0 24 57 13 C | 96 0 24 13 16 G | 0 96 24 13 54 T | 0 0 24 13 13scan! |
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updated Thu Sep 12 18:51:41 2024