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legend  pdf

structure nameTHE CRYSTAL STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH ID-130 AND DNA
referenceGarofalo et al. J.Med.Chem. 62 7445 2019
experimentX-ray (resolution=2.70, R-factor=0.228)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5npk_bd 6fm4_BD 7fvs_AB 7fvt_AB 7mvs_AB
reference complex5npk_d
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKSRI

Estimated binding specificities ?

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# IC=4.085 IC/col=0.681 n_of_columns=6 specificity:   
A |   9   9   9  24   0   0
C |  69  69   9  24  96   0
G |   9   9   9  24   0  96
T |   9   9  69  24   0   0
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updated Thu Sep 12 23:23:17 2024