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legend  pdf

structure nameTHE CRYSTAL STRUCTURE OF S. AUREUS GYRASE COMPLEX WITH ID-130 AND DNA
referenceGarofalo et al. J.Med.Chem. 62 7445 2019
experimentX-ray (resolution=2.70, R-factor=0.228)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes2xcr_BD 2xcr_SU 2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5cdo_ABCD 5cdo_RSTU 5cdq_ABCD 5cdq_RSTU 5cdr_AB 5cdr_CD 5iwi_AB 5iwi_CD 5iwm_ABCD 5npk_bd 6fm4_BD 6fqm_ABCD 6fqm_abcd 6fqv_ABCD 6fqv_RSTU 6qtk_ABCD 6qtp_ABCD 6qx1_ABCD 7fvs_AB 7fvt_AB 7mvs_AB
reference complex5iwi_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKSRI

Estimated binding specificities ?

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# IC=4.007 IC/col=0.668 n_of_columns=6 specificity:   
A |   0   0  24  69   9   9
C |  96   0  24   9   9  11
G |   0  96  24   9  67  67
T |   0   0  24   9  11   9
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updated Fri Jan 9 06:17:57 2026