7fvt_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF S. AUREUS GYRASE IN COMPLEX WITH 6-[5-[2-[(4- CHLORO-2,3-DIHYDRO-1H-INDEN-2-YL)METHYLAMINO]ETHYL]-2-OXO-1,3- OXAZOLIDIN-3-YL]-4H-PYRIDO[3,2-B][1,4]OXAZIN-3-ONE
reference	'Acs 2023 X-RAY DIFFRACTION
experiment	X-ray (resolution=2.08, R-factor=0.202)
structural superfamily	Type II DNA topoisomerase;
sequence family	DNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7fvt_A interface=42,44,205,264,265,302,355, kladcsskspeeceiflvegdsaggstksgrdsrtqailplRgKilnvekarldrilnnneirqmitafgtgiggdfdlakaryhkivimtdadvdgahirtllltffyrfmrplieagyvyiaqpptgykglgemnadqlwettmnpehrallqvkledaieadqtfemlmgdvvenrrqfiednavynernitsemresfldYamsvivaralpdvrdglkpvhrrilyglneqgmtpdksykksarivgdvmgkyhphgdSSiyeamvrmaqdfsyryplvdgqgnfgsmdgdgaaamRftearmtkitlellrdinkdtidfidnydgnerepsvlparfpnllangasgIavgmatnipphnltelingvlslsknpdisiaelmediegpdfptaglilgksgirrayetgrgsiqmrsravieergggrqrivvteipfqvnkarmiekiaelvrdkkidgitdlrdetslrtgvrvvidvrkdanasvilnnlykqtplqtsfgvnmialvngrpklinlkealvhylehqktvvrrrtqynlrkakdrahileglrialdhideiistiresdtdkvameslqqrfklsekqaqaildmrlrrltglerdkieaeynellnyiseletiladeevllqlvrdelteirdrfgddrrteiql
interface signature	RKYSSRI

Estimated binding specificities ?

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# IC=4.250 IC/col=0.354 n_of_columns=12

specificity:

A |   0   0  24  24  12  12  24  24  24  24  24  84
C |  96   0  24  24  12  12  24  24  24  24  24   0
G |   0  96  24  24  60  60  24  24  24  24  24   0
T |   0   0  24  24  12  12  24  24  24  24  24  12

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updated Tue Dec 17 09:15:14 2024