interface graph thumbnail
legend  pdf

structure nameDNA GYRASE COMPLEXED WITH UNCLEAVED DNA AND COMPOUND 7 TO 2.6A RESOLUTION
(DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT A)
referenceRatigan et al. J.Med.Chem. 64 15214 2021
sourceSTAPHYLOCOCCUS AUREUS
experimentX-ray (resolution=2.60, R-factor=0.197)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus; Toprim domain;
multimeric complexes2xcs_BD 4bul_AC 4plb_BD 5bs3_BD 5npk_bd 6fm4_BD 7fvs_AB 7fvt_AB 7mvs_AB
reference complex5npk_d
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKSERI

Estimated binding specificities ?

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# IC=3.142 IC/col=0.628 n_of_columns=5 specificity:   
A |  13  13  24   0   0
C |  57  13  24  96   0
G |  13  16  24   0  96
T |  13  54  24   0   0
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updated Fri Sep 13 04:53:58 2024