interface graph thumbnail
legend  pdf

structure nameMURINE NF-KAPPAB P50 REL HOMOLOGY REGION HOMODIMER IN COMPLEX WITH 17- MER KAPPAB DNA FROM HUMAN INTERLEUKIN-6 (IL-6) PROMOTER
(Nuclear factor NF-kappa-B p50 subunit)
referenceRogers et al. Biomolecules 13 ? 2023
sourceMus musculus
experimentX-ray (resolution=2.80, R-factor=0.227)
structural superfamilyp53-like transcription factors;E set domains;
sequence familyRel homology domain RHD; IPT/TIG domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRYCEHK

Estimated binding specificities ?

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# IC=3.319 IC/col=0.664 n_of_columns=5 specificity:   
A |  20  10   3   0   6
C |  16  10  82  95  80
G |  18  10   7   1   6
T |  42  66   4   0   4
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updated Tue Dec 17 20:05:50 2024