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structure nameMURINE NF-KAPPAB P50 REL HOMOLOGY REGION HOMODIMER IN COMPLEX WITH 17- MER KAPPAB DNA FROM HUMAN INTERLEUKIN-6 (IL-6) PROMOTER
(Nuclear factor NF-kappa-B p50 subunit)
referenceRogers et al. Biomolecules 13 ? 2023
sourceMus musculus
experimentX-ray (resolution=2.80, R-factor=0.227)
structural superfamilyp53-like transcription factors;E set domains;
sequence familyRel homology domain RHD; IPT/TIG domain;
multimeric complexes1le5_AB 1le5_EF 1le9_AB 1le9_EF 1lei_AB 1nfk_AB 1vkx_AB 2i9t_AB 2o61_AB 3gut_ABD 3gut_CF 3gut_EGH 8tkl_AB 8tkm_AB
reference complex1nfk_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRYCEHK

Estimated binding specificities ?

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# IC=3.466 IC/col=0.693 n_of_columns=5 specificity:   
A |   4   0   3  67  41
C |   6   0   5  10  18
G |  80  96  85   9  17
T |   6   0   3  10  20
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updated Fri Sep 13 13:48:59 2024