| structure name | HUMAN TOPOISOMERASE II ALPHA BOUND TO DNA (DNA topoisomerase 2-alpha) |
| reference | Wendorff et al. J.Mol.Biol. 424 109 2012 |
| source | Homo sapiens |
| experiment | X-ray (resolution=2.90, R-factor=0.229) |
| structural superfamily | Type II DNA topoisomerase; |
| sequence family | DNA gyrase/topoisomerase IV, subunit A; |
| redundant complexes | 5gwk_B |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | KDEIS |
Estimated binding specificities ?
| contact |  |
A | 16 54 24 0 0 C | 54 13 24 96 0 G | 13 16 24 0 96 T | 13 13 24 0 0scan! |
Dendrogram of similar interfaces ?
matrix format--KA--DC------------------------------ECIGSG-------------------------------------------- L +4fm9_A +------------------4 RAKG----------------QAAG----------------IGAG-------------------------------------------- L ! +5zen_A ! --KT------------------SA--------------EGIGSC-------------------------------------------- ! +------3l4j_A ! ! --KT----RC------------AT----------------IC------------------------RG-------------------- L ! +-7 +2xkk_C +----10 ! ! +-3 --KA------------------SA----------RG----IG---------------------------------------------- ! ! ! +----6 +2xcr_U ! ! ! ! RCKT------------------SA----------RG----IG--QT------------------------------------------ L ! ! +----8 +-5npk_d ! ! ! ! ----YT----------------ST------------RA--IG---------------------------------------------- ! ! ! ! +5bs8_A +-11 ! ! ! +-1 ----YC----------------SG----------RT----IG---------------------------------------------- ! ! +-----9 +-------2 +5iwi_C ! ! ! ! --------------------------------------------------------------------------------LAECDAKG ! ! ! +6n1p_A +-12 ! ! --------RC------------ST----------------IA---------------------------------------------- ! ! ! +-------------3ksb_B ! ! ! --KT------------------------------------------------------------------------------------ +-13 ! +-------------------------5bs8_D ! ! ! --KG------------------------------------------------------------------------------------ ! ! +--------------------------5iwi_D +-14 ! --------------RC--------------------SG-------------------------------------------------- ! ! +---------------------------7cow_T +-15 ! ----------QA------------------------NG-------------------------------------------------- ! ! +---------------------------7k63_U +-16 ! ----------------------------------------------TAFCAG--RC-------------------------------- L ! ! +----------------------------6dg0_A +-17 ! ------------------------NAST--RGHT------------------------------------------------------ L ! ! +----------------------------7cby_C +-18 ! ------------RC-------------------------------------------------------------------------- ! ! +-----------------------------6l9z_S ! ! --------------DT--RGRCTT----KT---------------------------------------------------------- L +-19 +-----------------------------2o9l_A ! ! --------------------------------------------------------------------NCAT--STRA---------- ! ! +-1a02_J +-20 +---------------------------5 ----------------------------------------------------------------------NCTTAT--RG-------- L ! ! +-2dgc_A -21 ! ----------------------------------------------TAFCSGLA--KATGTGSGVG---------------------- L ! +-----------------------------5tkz_B ! ----------------NT--TCTA------------RT-------------------------------------------------- L +-----------------------------5zux_A |
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updated Tue Dec 19 08:47:40 2023