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legend  pdf

structure nameHUMAN TOPOISOMERASE II ALPHA BOUND TO DNA
(DNA topoisomerase 2-alpha)
referenceWendorff et al. J.Mol.Biol. 424 109 2012
sourceHomo sapiens
experimentX-ray (resolution=2.90, R-factor=0.229)
structural superfamilyType II DNA topoisomerase;
sequence familyDNA gyrase/topoisomerase IV, subunit A;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKDEIS

Estimated binding specificities ?

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# IC=3.101 IC/col=0.620 n_of_columns=5 specificity:   
A |   0   0  24  13  13
C |  96   0  24  16  13
G |   0  96  24  13  54
T |   0   0  24  54  16
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --KA--DC------------------------------ECIGSG--------------------------------------------   L                                                          +4fm9_A    
                                                                                                                                     +------------------4 
  RAKG----------------QAAG----------------IGAG--------------------------------------------   L                                       !                  +5zen_A    
                                                                                                                                     !  
  --KT------------------SA--------------EGIGSC--------------------------------------------                                           !            +------3l4j_A    
                                                                                                                                     !            ! 
  --KT----RC------------AT----------------IC------------------------RG--------------------   L                                       !          +-7      +2xkk_C    
                                                                                                                               +----10          ! !    +-3 
  --KA------------------SA----------RG----IG----------------------------------------------                                     !     !          ! +----6 +2xcr_U    
                                                                                                                               !     !          !      ! 
  RCKT------------------SA----------RG----IG--QT------------------------------------------   L                                 !     !     +----8      +-5npk_d    
                                                                                                                               !     !     !    ! 
  ----YT----------------ST------------RA--IG----------------------------------------------                                     !     !     !    !         +5bs8_A    
                                                                                                                            +-11     !     !    !       +-1 
  ----YC----------------SG----------RT----IG----------------------------------------------                                  !  !     +-----9    +-------2 +5iwi_C    
                                                                                                                            !  !           !            ! 
  --------------------------------------------------------------------------------LAECDAKG                                  !  !           !            +6n1p_A    
                                                                                                                         +-12  !           ! 
  --------RC------------ST----------------IA----------------------------------------------                               !  !  !           +-------------3ksb_B    
                                                                                                                         !  !  !  
  --KT------------------------------------------------------------------------------------                            +-13  !  +-------------------------5bs8_D    
                                                                                                                      !  !  !  
  --KG------------------------------------------------------------------------------------                            !  !  +--------------------------5iwi_D    
                                                                                                                   +-14  !  
  --------------RC--------------------SG--------------------------------------------------                         !  !  +---------------------------7cow_T    
                                                                                                                +-15  !  
  ----------QA------------------------NG--------------------------------------------------                      !  !  +---------------------------7k63_U    
                                                                                                             +-16  !  
  ----------------------------------------------TAFCAG--RC--------------------------------   L               !  !  +----------------------------6dg0_A    
                                                                                                          +-17  !  
  ------------------------NAST--RGHT------------------------------------------------------   L            !  !  +----------------------------7cby_C    
                                                                                                       +-18  !  
  ------------RC--------------------------------------------------------------------------             !  !  +-----------------------------6l9z_S    
                                                                                                       !  !  
  --------------DT--RGRCTT----KT----------------------------------------------------------   L      +-19  +-----------------------------2o9l_A    
                                                                                                    !  !  
  --------------------------------------------------------------------NCAT--STRA----------          !  !                           +-1a02_J    
                                                                                                 +-20  +---------------------------5 
  ----------------------------------------------------------------------NCTTAT--RG--------   L   !  !                              +-2dgc_A    
                                                                                               -21  !  
  ----------------------------------------------TAFCSGLA--KATGTGSGVG----------------------   L   !  +-----------------------------5tkz_B    
                                                                                                 !  
  ----------------NT--TCTA------------RT--------------------------------------------------   L   +-----------------------------5zux_A    
                                                                                               

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updated Fri Sep 13 18:12:58 2024