4h0e_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF MUTANT ORR3 IN COMPLEX WITH NTD OF ARAR (Arabinose metabolism transcriptional repressor)
reference	Nair et al. 'Nucleic 41 639 2013
source	Bacillus Subtilis
experiment	X-ray (resolution=1.97, R-factor=0.221)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Bacterial regulatory proteins, gntR family;
multimeric complexes	4egy_AB 4egz_AB 4h0e_AB 5d4r_AB 5d4s_AB
redundant complexes	4egy_B 4egz_A 5d4r_B 5d4s_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4h0e_A interface=32,33,42,43,44,47,63, efmlpkyaqvkeeisswinqgkilpdqkiptENelmqqfgvSRHtiRkaigdlvsqgllysvQgggtfva
interface signature	ENSRHRQ

Estimated binding specificities ?

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# IC=4.779 IC/col=0.683 n_of_columns=7

specificity:

A |  16   0   0  16  24  16   0
C |  16   0   0  16  24  48   0
G |   0   0  96  16  24  16  96
T |  64  96   0  48  24  16   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: AraR
ATTTGTAC	PubMed	4h0e_A(1.62e-03), 4egy_AB(4.13e-03), 4h0e_AB(1.13e-02), ... (total=4)

Dendrogram of similar interfaces ?

matrix format

  
  VTSARGTA----RT--------------   L            +------------------------6za3_B    
                                            +-2 
  --EGRTRGRG--YT--------------   L          ! !     +------------------4yo2_A    
                                         +--3 +-----1 
  --------------RC----YG--KT--           !  !       +------------------2acj_B    
                                       +-4  ! 
  --ITRGECSC--SGKG------------   L     ! !  +--------------------------5i2d_R    
                                     +-5 ! 
  --------------------YG------       ! ! +-----------------------------3eyi_B    
                                   --6 ! 
  --RG----DTVT----ST--------WT   L   ! +-----------------------------6lxn_A    
                                     ! 
  ------------NAST--RTHTST----   L   +-----------------------------3l2c_A

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updated Sat Jan 10 07:05:51 2026