interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF CIC-HMG-ETV5-DNA COMPLEX
(Protein capicua homolog)
referenceSong et al. 'Febs 286 4951 2019
sourceHomo sapiens
experimentX-ray (resolution=3.00, R-factor=0.301)
structural superfamilyHMG-box;
sequence familyHMG high mobility group box;
multimeric complexes6jrp_AD 6jrp_GJ
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRNFMRDNRSN

Estimated binding specificities ?

readout + contactlogo
# IC=6.016 IC/col=0.859 n_of_columns=7 specificity:   
A |  76  83   0   6  89  72  70
C |   8   6   0   0   0  12   6
G |   6   6   0  89   0   6  12
T |   6   1  96   1   7   6   8
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RTNGFTIA--RA--NASG--ST----YAPG   L      +-----------------------------1j47_A    
                                          !  
  RCNTFTMA--RAHTNTAT--SA----YA--   L      !                                            +3u2b_C    
                                          !                                          +-1 
  RTNTFTMA--RA--NGAC--ST----YA--   L      !                       +------------------5 +4s2q_D    
                                          !                       !                  ! 
  RCNTFTMA--RAHGNAAC--ST--------   L      !                       !                  +4euw_A    
                                          !                       ! 
  RTNAFA----RCDTNTRA--ST------NT   L      !                     +-8                    +6jrp_D    
                                          !                     ! !                  +-2 
  KCNT--MAMA--EGSAAC--NT--------   L      !                     ! !      +-----------4 +2lef_A    
                                          !                     ! !      !           ! 
  RCNGFTMA--RTHTNG----ST----YA--   L      !                 +---9 +------6           +6t90_L    
                                          !                 !   !        ! 
  KASTYGLASGLA--TGTC--IT--------   L   +-16                 !   !        +------------3tmm_A    
                                       !  !              +-10   ! 
  RTNTFTMA--RT--NG----SA----YA--   L   !  !              !  !   +---------------------4y60_C    
                                       !  !           +-11  !  
  RCNTFTMA--RA--NGSC--ST----YA--       !  !           !  !  +-------------------------1gt0_D    
                                       !  !        +-12  !  
  --NAFTIA--RC----SGICST----YA--   L   !  !        !  !  +--------------------------1hry_A    
                                       !  !        !  !  
  --------VT----FG--FCSA--------       !  !     +-13  +--------------------------4qr9_A    
                                       !  !     !  !  
  RTSAYCMT------FT--------------   L -17  !     !  !                           +1j5n_A    
                                       !  !  +-14  +---------------------------3 
  RC--YTMALTRA--VCTG--AAVCEC----   L   !  !  !  !                              +1qrv_A    
                                       !  !  !  !  
  RTNAFTIA--RA--NT----SA--------   L   !  +-15  +---------------------------6edb_B    
                                       !     !  
  ----FTIA--RT--QTLA--MT--------   L   !     !         +-----------------5jh0_D    
                                       !     +---------7 
  ------FTCA----IG----AT--------       !               +-----------------6oem_H    
                                       !  
  RTNGFTMA--RT--NTAT--SA----YAPT   L   +-----------------------------6t78_A    
                                     

home
updated Tue Dec 19 13:23:21 2023