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structure nameCRYO-EM STRUCTURE OF YEAST MITOCHONDRIAL RNA POLYMERASE PARTIALLY- MELTED TRANSCRIPTION INITIATION COMPLEX (PMIC)
experimentNMR
structural superfamilyDNA/RNA polymerases;
sequence familyDNAdependent RNA polymerase;
multimeric complexes6ymv_AB 6ymw_AB 8ap1_AB 8att_AB 8atv_AB 8atw_AB 8c5s_AB 8c5u_AB 8q63_AB
redundant complexes8atw_A 8q63_A 6ymw 8ap1 8att 8atv 8c5s 8c5u
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYHSKQFR

Estimated binding specificities ?

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# IC=3.226 IC/col=0.461 n_of_columns=7 specificity:   
A |  12  96   0  24  24  22  13
C |  12   0   0  24  24  22  14
G |  12   0   0  24  24  30  13
T |  60   0  96  24  24  22  56
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------------------------YTHASAKT--------------------------------------QAFTRG------   L                          +-----------6ymv_A    
                                                                                                         +----------1 
  --------QG--------------SC--RG----IC----------SC----EG------------QGTGYG----RG------   L         +-----2          +-----------4boc_A    
                                                                                                   !     ! 
  ------------------------------------RGATYTDGKG----------RCRCYC------------------HT--   L       +-3     +----------------------1msw_D    
                                                                                                 ! ! 
  ------------------------------------------------KT----YG--RG--NG--------------QA--HG         +-4 +----------------------------4yfu_D    
                                                                                               ! ! 
  KTATFCRC--DCSCWCRAITNTNG------------------------------------------------------------   L   +-5 +-----------------------------4lup_A    
                                                                                             ! ! 
  ------------------------------------------------KC----------RT----------------------     --6 +-----------------------------6fbc_A    
                                                                                             ! 
  --------------------------------------------------RC------RA--NGNG------------------   L   +-----------------------------6vdd_A    
                                                                                           

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updated Sat Sep 14 00:53:33 2024