interface graph thumbnail
legend  pdf

structure nameX-RAY STRUCTURE OF INTERFERON REGULATORY FACTOR 4 DNA BINDING DOMAIN BOUND TO AN INTERFERON-STIMULATED RESPONSE ELEMENT SOLVED BY PHOSPHORUS AND SULPHUR SAD METHODS
(Interferon regulatory factor 4)
referenceAgnarelli et al. 'Acta 77 202 2021
sourceHomo sapiens
experimentX-ray (resolution=2.60, R-factor=0.214)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInterferon regulatory factor transcription f;
multimeric complexes7jm4_GH 7o56_AB 7ogs_AB 7ogs_EF 7oot_AB 7rh2_GH 8jkl_CD 8jkl_GH 8jkq_DG 8jkq_FH 8jks_CD 8jks_GH
reference complex7oot_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureTRCK

Estimated binding specificities ?

readout + contactlogo
# IC=4.277 IC/col=0.713 n_of_columns=6 specificity:   
A |   0  15   5  11   5   5
C |   0  11   6  10  80   5
G |  96   5   5  15   5   6
T |   0  65  80  60   6  80
scan!

Dendrogram of similar interfaces ?

matrix format

home
updated Sun Jun 28 23:59:04 2026