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structure nameX-RAY STRUCTURE OF INTERFERON REGULATORY FACTOR 4 DNA BINDING DOMAIN BOUND TO AN INTERFERON-STIMULATED RESPONSE ELEMENT
(Interferon regulatory factor 4)
referenceAgnarelli et al. 'To ? ? ?
sourceHomo sapiens
experimentX-ray (resolution=2.25, R-factor=0.204)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInterferon regulatory factor transcription f;
multimeric complexes7jm4_GH 7o56_AB 7ogs_AB 7ogs_EF 7oot_AB 7rh2_GH 8jkl_CD 8jkl_GH 8jkq_DG 8jkq_FH 8jks_CD 8jks_GH
redundant complexes7jm4_G 7o56_A 7ogs_A 7rh2_B 8jkl_G 8jkn_G 8jko_G 8jkq_H 8jks_D
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureTRCNK

Estimated binding specificities ?

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# IC=6.186 IC/col=0.884 n_of_columns=7 specificity:   
A |   0   4  64  84  81   0   4
C |   0  12   9   4   7  96  84
G |   0  76  14   4   4   0   4
T |  96   4   9   4   4   0   4
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Dendrogram of similar interfaces ?

matrix format
  
  ECKT--RGAT--RGHT----RA--   L                                +---4mhg_A    
                                                            +-1 
  --KT--RG----RGYT--------   L     +------------------------2 +---4bqa_A    
                                   !                        ! 
  --KT--RG----RGYA--------   L   +-3                        +----4l18_B    
                                 ! ! 
  ------NASTRGHT--ST------   L --4 +-----------------------------2uzk_A    
                                 ! 
  ----NAST--RGHT--STLT--KA   L   +-----------------------------2c6y_A    
                               

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updated Sat Sep 14 03:35:46 2024