7oot_B : 3D-footprint complex

structure name	X-RAY STRUCTURE OF INTERFERON REGULATORY FACTOR 4 DNA BINDING DOMAIN BOUND TO AN INTERFERON-STIMULATED RESPONSE ELEMENT (Interferon regulatory factor 4)
reference	Agnarelli et al. 'To ? ? ?
source	Homo sapiens
experiment	X-ray (resolution=2.25, R-factor=0.204)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Interferon regulatory factor transcription f;
multimeric complexes	7jm4_GH 7o56_AB 7ogs_AB 7ogs_EF 7oot_AB 7rh2_GH 8jkl_CD 8jkl_GH 8jkq_DG 8jkq_FH 8jks_CD 8jks_GH
redundant complexes	7jm4_G 7o56_A 7ogs_A 7rh2_B 8jkl_G 8jkn_G 8jko_G 8jkq_H 8jks_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7oot_B interface=74,77,78,81,82, gklrqwlidqidsgkypglvweneeksifripwkhagkqdynreedaalfkawalfkgkfregidkpdpptwkTrlRCalNKsndfeelversqldisdpykvyrivpega
interface signature	TRCNK

Estimated binding specificities ?

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# IC=6.038 IC/col=0.863 n_of_columns=7

specificity:

A |   0   5  65  80  80   0   5
C |   0   5  16   5   6  96  80
G |   0  80   5   6   5   0   5
T |  96   6  10   5   5   0   6

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Dendrogram of similar interfaces ?

matrix format

  
  HT----ATNTRGCT----SC   L                          +--------8hcm_A    
                                       +------------1 
  --DCKTRG----RGYA----   L     +-------2            +--------3zp5_A    
                               !       ! 
  ------------RG--NG--       +-3       +---------------------7dci_A    
                             ! ! 
  --DCKTRGST--RGYC----   L --4 +-----------------------------4uno_A    
                             ! 
  ------NASTRTHTNTSTLT   L   +-----------------------------3co6_C

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updated Tue Jun 30 06:35:26 2026