7oot_B : 3D-footprint complex

structure name	X-RAY STRUCTURE OF INTERFERON REGULATORY FACTOR 4 DNA BINDING DOMAIN BOUND TO AN INTERFERON-STIMULATED RESPONSE ELEMENT (Interferon regulatory factor 4)
reference	Agnarelli et al. 'To ? ? ?
source	Homo sapiens
experiment	X-ray (resolution=2.25, R-factor=0.204)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Interferon regulatory factor transcription f;
multimeric complexes	7jm4_GH 7o56_AB 7ogs_AB 7ogs_EF 7oot_AB 7rh2_GH 8jkl_CD 8jkl_GH 8jkq_DG 8jkq_FH 8jks_CD 8jks_GH
redundant complexes	7jm4_G 7o56_A 7ogs_A 7rh2_B 8jkl_G 8jkn_G 8jko_G 8jkq_H 8jks_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7oot_B interface=74,77,78,81,82, gklrqwlidqidsgkypglvweneeksifripwkhagkqdynreedaalfkawalfkgkfregidkpdpptwkTrlRCalNKsndfeelversqldisdpykvyrivpega
interface signature	TRCNK

Estimated binding specificities ?

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# IC=6.152 IC/col=0.879 n_of_columns=7

specificity:

A |   5   0   5   0   5  20  96
C |   6   0   5   0   5  50   0
G |  80  96   5   0  21  16   0
T |   5   0  81  96  65  10   0

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Dendrogram of similar interfaces ?

matrix format

  
  ECKT--RGAT--RGHT----RA--   L                                +---4mhg_A    
                                                            +-1 
  --KT--RG----RGYT--------   L     +------------------------2 +---4bqa_A    
                                   !                        ! 
  --KT--RG----RGYA--------   L   +-3                        +----4l18_B    
                                 ! ! 
  ------NASTRGHT--ST------   L --4 +-----------------------------2uzk_A    
                                 ! 
  ----NAST--RGHT--STLT--KA   L   +-----------------------------2c6y_A

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updated Sun Aug 3 17:29:08 2025