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structure nameT95R MUTANT IRF4 DNA-BINDING DOMAIN BOUND TO AN DNA CONTAINING GAAA MOTIF
(Interferon regulatory factor 4)
referenceWang et al. Structure 31 1441 2023
sourceHomo sapiens
experimentX-ray (resolution=2.92, R-factor=0.221)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInterferon regulatory factor transcription f;
multimeric complexes7jm4_GH 7o56_AB 7ogs_AB 7ogs_EF 7oot_AB 7rh2_GH 8jkl_CD 8jkl_GH 8jkq_DG 8jkq_FH 8jks_CD 8jks_GH
reference complex7oot_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRCK

Estimated binding specificities ?

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# IC=4.815 IC/col=0.803 n_of_columns=6 specificity:   
A |   0   6   5  20   5  96
C |   0   5  21  15  81   0
G |  96   5   5  11   5   0
T |   0  80  65  50   5   0
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updated Mon Jun 29 09:15:30 2026