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structure nameT95R MUTANT IRF4 DNA-BINDING DOMAIN BOUND TO AN DNA CONTAINING GATA MOTIF
(Interferon regulatory factor 4)
referenceWang et al. Structure 31 1441 2023
sourceHomo sapiens
experimentX-ray (resolution=2.95, R-factor=0.232)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInterferon regulatory factor transcription f;
multimeric complexes7jm4_GH 7o56_AB 7ogs_AB 7ogs_EF 7oot_AB 7rh2_GH 8jkl_CD 8jkl_GH 8jkq_DG 8jkq_FH 8jks_CD 8jks_GH
reference complex7oot_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRCK

Estimated binding specificities ?

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# IC=5.300 IC/col=0.883 n_of_columns=6 specificity:   
A |   0   9  67   9  96   0
C |   0   9   9  11   0  96
G |   0  67  11   9   0   0
T |  96  11   9  67   0   0
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updated Fri Jan 9 23:56:02 2026