interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF PHOSPHORYLATED ETS1, RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
(PROTEIN C-ETS-1)
referenceShiina et al. J.Mol.Biol. 427 1655 2015
sourceHOMO SAPIENS
experimentX-ray (resolution=2.35, R-factor=0.241)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes1mdm_AB 2nny_AB 3mfk_AB 3wts_AC 3wtt_AC 3wtu_AC 3wtv_AC 3wtw_AC 3wtx_AC 3wty_AC 4l0y_AB 4l0z_AB 4l18_AB 4l18_EF
reference complex4l18_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRRY

Estimated binding specificities ?

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# IC=3.142 IC/col=0.786 n_of_columns=4 specificity:   
A |  13   0   0  16
C |  13  96  96  13
G |  13   0   0  13
T |  57   0   0  54
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updated Thu Sep 12 18:38:20 2024