interface graph thumbnail
legend  pdf

structure nameSOLUTION NMR STRUCTURE OF THE HUMAN ETS1/DNA COMPLEX, 25 STRUCTURES
experimentNMR
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes1mdm_AB 2nny_AB 3mfk_AB 3wts_AC 3wtt_AC 3wtu_AC 3wtv_AC 3wtw_AC 3wtx_AC 3wty_AC 3wu1_AB 4l0y_AB 4l0z_AB 4l18_AB 4l18_EF 4lg0_AB
redundant complexes1k79_D 1k7a_A 1mdm_B 2nny_A 2stw_A 3mfk_A 3wtt_H 3wtu_C 3wtw_C 3wtx_C 4l0y_B 4l0z_B 5zmc_B 3wts 3wtv 3wty 3wu1 4l18 4lg0
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureESRRY

Estimated binding specificities ?

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# IC=4.434 IC/col=0.887 n_of_columns=5 specificity:   
A |  13   0   0   0  13
C |  13  96  96   0  13
G |  16   0   0  96  54
T |  54   0   0   0  16
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Dendrogram of similar interfaces ?

matrix format
  
  ECKTRGATRGNT----   L       +-----------------------------1pue_E    
                           +-2 
  DCKTRG--RGYA--KA   L     ! +-----------------------------5jvt_A    
                         +-3 
  DCKTRGSTRGYA----   L   ! !               +-------------4bnc_A    
                       --4 +---------------1 
  ----RGNT----RA--   L   !                 +-------------2o6g_G    
                         ! 
  QCKTRGATRGNT----   L   +-----------------------------8smh_F    
                       

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updated Mon Jun 29 15:39:28 2026