interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1 (V170A), RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
referenceShiina et al. J.Mol.Biol. 427 1655 2015
experimentX-ray (resolution=2.70, R-factor=0.232)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes1mdm_AB 2nny_AB 3mfk_AB 3wts_AC 3wtt_AC 3wtu_AC 3wtv_AC 3wtw_AC 3wtx_AC 3wty_AC 4l0y_AB 4l0z_AB 4l18_AB 4l18_EF
reference complex4l18_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRRY

Estimated binding specificities ?

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# IC=3.101 IC/col=0.775 n_of_columns=4 specificity:   
A |  16   0   0  16
C |  13  96  96  13
G |  13   0   0  13
T |  54   0   0  54
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updated Thu Sep 12 18:38:29 2024