interface graph thumbnail
legend  pdf

structure nameSTRUCTURAL BASIS FOR REACTIVATION OF -146C>T MUTANT TERT PROMOTER BY COOPERATIVE BINDING OF P52 AND ETS1/2
(PROTEIN C-ETS-1)
referenceBharath et al. 'Nat 9 3183 2018
sourceHOMO SAPIENS
experimentX-ray (resolution=2.99, R-factor=0.260)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes3wu1_AB 4lg0_AB
reference complex4lg0_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRRY

Estimated binding specificities ?

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# IC=5.300 IC/col=0.883 n_of_columns=6 specificity:   
A |   9   0   0  96  67   9
C |  67   0   0   0   9   9
G |  11  96  96   0  11  67
T |   9   0   0   0   9  11
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updated Thu Sep 12 22:39:02 2024