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structure nameSTRUCTURAL BASIS FOR REACTIVATION OF -146C>T MUTANT TERT PROMOTER BY COOPERATIVE BINDING OF P52 AND ETS1/2
(PROTEIN C-ETS-1)
referenceBharath et al. 'Nat 9 3183 2018
sourceHOMO SAPIENS
experimentX-ray (resolution=2.99, R-factor=0.260)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes1mdm_AB 2nny_AB 3mfk_AB 3wts_AC 3wtt_AC 3wtu_AC 3wtv_AC 3wtw_AC 3wtx_AC 3wty_AC 3wu1_AB 4l0y_AB 4l0z_AB 4l18_AB 4l18_EF 4lg0_AB
reference complex4lg0_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRRY

Estimated binding specificities ?

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# IC=5.300 IC/col=0.883 n_of_columns=6 specificity:   
A |  11   9   0   0   0   9
C |  67   9   0  96  96  11
G |   9  11   0   0   0  67
T |   9  67  96   0   0   9
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updated Fri Jan 9 05:17:52 2026