2e42_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF C/EBPBETA BZIP HOMODIMER V285A MUTANT BOUND TO A HIGH AFFINITY DNA FRAGMENT (CCAATenhancer-binding protein beta)
reference	Inoue-Bungo et al. 'To ? ? ?
source	Homo sapiens
experiment	X-ray (resolution=1.80, R-factor=0.232)
structural superfamily	Leucine zipper domain;
sequence family	Basic region leucine zipper; bZIP transcription factor;
redundant complexes	1hjb 2e43 1h89 1h88 1gu4 1io4 1h8a 1gu5 1gtw
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2e42_B interface=11,14,15,17,18,21,22, dkhsdeykirRerNNiAArkSRdkakmrnletqhkvleltaenerlqkkveqlsrelstlrnlfkql
interface signature	RNNAASR

Estimated binding specificities ?

readout + contact

# IC=3.555 IC/col=0.889 n_of_columns=4

specificity:

A |  20   0  76  96
C |  19  96   0   0
G |  38   0  20   0
T |  19   0   0   0

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: C/EBPBETA
CAATT	PubMed	1gtw_AB(4.33e-03), 1gu4_AB(4.06e-03), 2e42_AB(2.94e-03), ... (total=7)
CCAAT	PubMed	1gtw_AB(4.33e-03), 1gu4_AB(4.06e-03), 1gu5_AB(6.59e-03), ... (total=8)

Dendrogram of similar interfaces ?

matrix format

  
  ----RA--NANCATAT--STRG   L        +2e42_B    
                                  +-4 
  RGQGNARTAGQT--FTRG----   L      ! +1gd2_F    
                               +--7 
  --------NCRTATAT--STRG   L   !  !  +1t2k_D    
                               !  +--2 
  ----RC--NANCAAVT----RG   L   !     +1nwq_A    
                             --8 
  --------NT--ATAT--STRC   L   !       +1jnm_A    
                               !     +-3 
  --------NCRTATAT--STRG   L   !   +-5 +1dh3_A    
                               !   ! ! 
  --------NC--AAAT----RT   L   +---6 +1a02_F    
                                   ! 
  --------NCTT--AT----RG   L       ! +2dgc_A    
                                   +-1 
  --------NT--ATAT--STRA   L         +2c9l_Y

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updated Mon Dec 16 19:28:58 2024