interface graph thumbnail
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structure nameGLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN IN COMPLEX WITH METHYLATED PRECURSOR FOR A MODERN RECOGNITION ELEMENT (METHYLATED PRE-GBS)
(Glucocorticoid receptor)
referenceOrtlund et al. 'Nucleic 49 8923 2021
sourceHomo sapiens
experimentX-ray (resolution=2.00, R-factor=0.183)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes1glu_AB 5va0_AB 5va7_AB 6x6d_AB 6x6e_AB
redundant complexes6x6d_B 5va0_B 5va7_B 6bqu_A 1glu_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVR

Estimated binding specificities ?

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# IC=3.101 IC/col=0.620 n_of_columns=5 specificity:   
A |   0   0  24  13  16
C |   0   0  24  54  13
G |  96   0  24  16  13
T |   0  96  24  13  54
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ECKG--KGRG       +-----------------------------3dzy_A    
                   !  
  DAKG--RGRG   L   !       +---------------------4iqr_B    
                   !  +---10  
  ECKGAGKGRG   L   !  !    +---------------------1hcq_E    
                 -14  !  
  DGKG--RTRG   L   !  !                           +3cbb_A    
                   !  !                +----------1 
  ECKG--KGRG   L   !  !                !          +2ff0_A    
                   !  !                ! 
  ECKG--RGRG   L   +-13  +-------------7       +---2nll_B    
                      !  !             ! +-----5 
  --KGVT--RG          !  !             ! !     +---5emp_A    
                      !  !             +-6 
  --KAVA--RA   L      !  !               !        +5e69_A    
                      !  !               +--------3 
  ECKG--RGRG   L      !  !                        +3dzy_D    
                      +-12  
  --KGVT--RG   L         !                         +6x6e_A    
                         !           +-------------2 
  ECKG--RGRG   L         !      +----8             +5uan_B    
                         !      !    ! 
  ECKG--KGRG             !  +---9    +--------------4nqa_H    
                         !  !   ! 
  ECKG--RGRG   L         !  !   !                 +-1dsz_A    
                         +-11   +-----------------4 
  ETKGAT--RG   L            !                     +-1lat_A    
                            !  
  --KGVG--RG   L            +-----------------------4tnt_B    
                 

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updated Fri Dec 23 02:14:06 2022